Viral interference with antigen presentation

Jonathan W. Yewdell, Ann B. Hill

Research output: Contribution to journalReview articlepeer-review

167 Scopus citations


CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral interference with antigen presentation; in particular we consider the importance (and difficulty) of establishing the evolutionary significance (that is, the ability to enhance viral transmission) of viral gene products that interfere with antigen presentation in vitro.

Original languageEnglish (US)
Pages (from-to)1019-1025
Number of pages7
JournalNature Immunology
Issue number11
StatePublished - Nov 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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