Volumetric imaging of blood flow within cochlea in gerbil in vivo

Niloy Choudhury; Fangyi Chen; Xiaorui Shi; Alfred L. Nuttall; Ruikang K. Wang

doi:10.1109/JSTQE.2009.2032671

Volumetric imaging of blood flow within cochlea in gerbil in vivo

Niloy Choudhury
, Fangyi Chen
, Xiaorui Shi
, Alfred L. Nuttall
, Ruikang K. Wang

Otolaryngology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Menieres disease. Advances have been made in the areas of vital microscopic studies of microcirculation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo 3-D mapping of microvascular perfusion within the cochlea. To overcome this limitation, we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques.

Original language	English (US)
Article number	5299290
Pages (from-to)	524-529
Number of pages	6
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	16
Issue number	3
DOIs	https://doi.org/10.1109/JSTQE.2009.2032671
State	Published - May 2010

Funding

Manuscript received July 14, 2009; revised August 21, 2009; accepted September 11, 2009. Date of publication October 30, 2009; date of current version June 4, 2010. This work was supported in part by the National Institute of Deafness and Other Communication Disorders under Grant DC010201, Grant DC 00105, and Grant DC 8888, by the National Heart, Lung, and Blood Institute under Grant HL093140, and by the American Heart Association under Grant 0855733G.

Funders	Funder number
National Institute of Health National Heart, Lung, and Blood Institute	HL093140
National Institute on Deafness and Other Communication Disorders R01DC012546 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC012115 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC014427 Ulrich Müller Peter G Barr-Gillespie National Institute on Deafnessand Other Communication Disorders R01DC005965 Ulrich Müller National Institute on Deafness and Other Communication Disorders	DC010201, DC 00105, DC 8888
American Heart Association/American Stroke Association	0855733G

Keywords

Biomedical imaging
Cochlear blood flow
Optical coherence tomography
Optical microangiography

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2009.2032671

Cite this

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title = "Volumetric imaging of blood flow within cochlea in gerbil in vivo",

abstract = "Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Menieres disease. Advances have been made in the areas of vital microscopic studies of microcirculation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo 3-D mapping of microvascular perfusion within the cochlea. To overcome this limitation, we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques.",

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note = "Funding Information: Manuscript received July 14, 2009; revised August 21, 2009; accepted September 11, 2009. Date of publication October 30, 2009; date of current version June 4, 2010. This work was supported in part by the National Institute of Deafness and Other Communication Disorders under Grant DC010201, Grant DC 00105, and Grant DC 8888, by the National Heart, Lung, and Blood Institute under Grant HL093140, and by the American Heart Association under Grant 0855733G.",

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N1 - Funding Information: Manuscript received July 14, 2009; revised August 21, 2009; accepted September 11, 2009. Date of publication October 30, 2009; date of current version June 4, 2010. This work was supported in part by the National Institute of Deafness and Other Communication Disorders under Grant DC010201, Grant DC 00105, and Grant DC 8888, by the National Heart, Lung, and Blood Institute under Grant HL093140, and by the American Heart Association under Grant 0855733G.

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N2 - Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Menieres disease. Advances have been made in the areas of vital microscopic studies of microcirculation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo 3-D mapping of microvascular perfusion within the cochlea. To overcome this limitation, we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques.

AB - Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Menieres disease. Advances have been made in the areas of vital microscopic studies of microcirculation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo 3-D mapping of microvascular perfusion within the cochlea. To overcome this limitation, we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques.

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Volumetric imaging of blood flow within cochlea in gerbil in vivo

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