Volumetric measurement of Henle's fiber layer and outer nuclear layer thickness using directional optical coherence tomography

Shanjida Khan, Shuibin Ni, Thanh Tin P. Nguyen, Ringo Ng, Brandon J. Lujan, Ou Tan, David Huang, Yifan Jian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Thinning of the outer nuclear layer (ONL) is an important pathological feature and possible biomarker of age-related macular degeneration (AMD). The demarcation of the ONL and Henle's fiber layer (HFL) is visually unattainable with standard optical coherence tomography (OCT) imaging. In this work, we built a volumetric directional OCT prototype which constitutes two optical scanners in the sample arm that synchronously scan the imaging beam on the pupil and retina. The imaging beam's entry positions and incident angles on the pupil and retina respectively are precisely controlled and optimally maintained to generate sufficient contrast of the HFL over the entire macular volume.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI
EditorsJoseph A. Izatt, James G. Fujimoto
PublisherSPIE
ISBN (Electronic)9781510647671
DOIs
StatePublished - 2022
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI 2022 - San Francisco, United States
Duration: Jan 24 2022Jan 26 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11948
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI 2022
Country/TerritoryUnited States
CitySan Francisco
Period1/24/221/26/22

Keywords

  • Henle's fiber layer
  • direction optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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