TY - JOUR
T1 - Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]
AU - Verstraete, Hans R.G.W.
AU - Heisler, Morgan
AU - Ju, Myeong Jin
AU - Wahl, Daniel
AU - Bliek, Laurens
AU - Kalkman, Jeroen
AU - Bonora, Stefano
AU - Jian, Yifan
AU - Verhaegen, Michel
AU - Sarunic, Marinko V.
N1 - Publisher Copyright:
© 2017 Optical Society of America.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the data-based online nonlinear extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.
AB - In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the data-based online nonlinear extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.
KW - Active or adaptive optics
KW - Algorithms
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85017029859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017029859&partnerID=8YFLogxK
U2 - 10.1364/BOE.8.002261
DO - 10.1364/BOE.8.002261
M3 - Article
AN - SCOPUS:85017029859
SN - 2156-7085
VL - 8
SP - 2261
EP - 2275
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 4
M1 - #280260
ER -