TY - JOUR
T1 - Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels
AU - Sailer, Carrie A.
AU - Pott, Gregory B.
AU - Dinarello, Charles A.
AU - Whinney, Samantha Ma
AU - Forster, Jeri E.
AU - Larson-Duran, Jacqueline K.
AU - Landay, Alan
AU - Al-Harthi, Lena
AU - Schooley, Robert T.
AU - Benson, Constance A.
AU - Judson, Franklyn N.
AU - Thompson, Melanie
AU - Palella, Frank J.
AU - Shapiro, Leland
N1 - Funding Information:
Received 19 July 2006; accepted 18 October 2006; electronically published 18 January 2007. Potential conflicts of interest: none reported. Presented in part: 12th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, 22–25 February 2005 (abstract D-165). Financial support: National Institutes of Health Program (project grants 5 P01 AI055356-02 and AI 15614). a Present affiliations: University of California, San Diego (R.T.S. and C.A.B.); University of Colorado at Denver and Health Sciences Center, Denver (F.N.J.). Reprints or correspondence: Dr. Leland Shapiro, Dept. of Medicine, Div. of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 E. 9th Ave. Box B168, Denver, CO 80262 (Leland.Shapiro@uchsc.edu).
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.
AB - Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.
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U2 - 10.1086/511435
DO - 10.1086/511435
M3 - Article
C2 - 17262717
AN - SCOPUS:33847074620
SN - 0022-1899
VL - 195
SP - 734
EP - 738
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -