@article{71a6198de1494ca3800fb35dac59230b,
title = "Work productivity and activity impairment in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery—A prospective, multi-institutional study",
abstract = "Background: Productivity loss and activity limitations due to chronic rhinosinusitis (CRS) are known to contribute to the significant economic and personal burden of disease. The purpose of this study was to assess productivity and activity impairment before and after endoscopic sinus surgery (ESS) for medically refractory CRS. Methods: This investigation was a prospective, multi-institutional, observational cohort study. Patients diagnosed with medically refractory CRS completed the Work Productivity and Activity Impairment—Specific Health Problem (WPAI-SHP) questionnaire before surgery and approximately 6 months after the procedure. Factors associated with minimal clinical important differences (MCIDs) for productivity and activity impairment were identified. Results: A total of 279 study participants were screened for inclusion, of whom 176 (63.1%) with postoperative follow-up were included in the final cohort. Preoperative productivity and activity impairment were observed in 63.2% and 69.8% of the patients, respectively. Among these patients, postoperative improvement equaling at least 1 MCID was reported in both productivity (76.1%) and activity (76.4%) impairments. Multivariate regression identified sphenoidotomy (odds ratio [OR], 4.18; 95% confidence interval [CI], 1.03-17.02) as the only factor associated with increased likelihood of productivity improvement, whereas septoplasty during ESS (OR, 8.45; 95% CI, 2.33-30.68) and migraine (OR, 0.35; 95% CI, 0.12-0.96) were associated with differential odds of activity improvement. Conclusion: CRS is associated with a substantial burden on productivity and activity that significantly improves after treatment with ESS. These data may facilitate improved patient counseling and shared decision-making regarding surgical management for CRS.",
keywords = "efficiency, quality of life, sinusitis, surgery, treatment outcome",
author = "Pandrangi, {Vivek C.} and Mace, {Jess C.} and Kim, {Jee Hong} and Mathew Geltzeiler and Detwiller, {Kara Y.} and Soler, {Zachary M.} and Schlosser, {Rodney J.} and Alt, {Jeremiah A.} and Ramakrishnan, {Vijay R.} and Mattos, {Jose L.} and Smith, {Timothy L.}",
note = "Funding Information: Enrollment originated from an observational, prospective research investigation of human subjects funded by the National Institute on Deafness and Other Communication Disorders (Bethesda, MD; 3R01‐DC005805). Participants were enrolled by invitation from heterogeneous patient populations presenting to the following academic rhinology centers in the United States: Oregon Health & Science University (Portland, OR), Medical University of South Carolina (Charleston, SC), University of Utah (Salt Lake City, UT), University of Colorado (Aurora, CO), and University of Virginia (Charlottesville, VA). The institutional review board at each site provided ethics review and oversight. Participants were excluded from final cohort selection if they provided incomplete or inaccurate responses to patient‐reported outcome measures during the study. Funding Information: National Institute on Deafness and Other Communication Disorders of the National Institutes for Health, Grant Number: 3R01‐DC005805 (co‐principal investigators: T.L.S. and Z.M.S.) to T.L.S., Z.M.S., R.J.S., J.A.A., V.R.R., and J.C.M. Funding Information: National Institute on Deafness and Other Communication Disorders of the National Institutes for Health, Grant Number: 3R01-DC005805 (co-principal investigators: T.L.S. and Z.M.S.) to T.L.S., Z.M.S., R.J.S., J.A.A., V.R.R., and J.C.M. Public clinical trial registration (www.clinicaltrials.gov) ID# NCT02720653. This funding organization did not contribute to the design or conduct of this study; preparation, review, approval, or decision to submit this manuscript for publication. Publisher Copyright: {\textcopyright} 2022 ARS-AAOA, LLC.",
year = "2023",
month = mar,
doi = "10.1002/alr.23070",
language = "English (US)",
volume = "13",
pages = "216--229",
journal = "International Forum of Allergy and Rhinology",
issn = "2042-6976",
publisher = "Wiley-Blackwell",
number = "3",
}