Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy

Victoria Hwang; Eduardo Mendez; Laura Q.M. Chow; Neal David Futran; Peter Andersen; Ryan Li; Vasu Divi; Cristina P. Rodriguez

doi:10.1002/lary.27902

Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy

Victoria Hwang, Eduardo Mendez, Laura Q.M. Chow, Neal David Futran, Peter Andersen, Ryan Li, Vasu Divi, Cristina P. Rodriguez

Otolaryngology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti–PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 129:E428–E433, 2019.

Original language	English (US)
Pages (from-to)	E428-E433
Journal	Laryngoscope
Volume	129
Issue number	12
DOIs	https://doi.org/10.1002/lary.27902
State	Published - Dec 1 2019

Keywords

Head and neck cancer
checkpoint inhibitors
head and neck squamous cell carcinoma
immunotherapy
monoclonal antibodies
osteoradionecrosis

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/lary.27902

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title = "Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy",

abstract = "Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti–PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 129:E428–E433, 2019.",

keywords = "Head and neck cancer, checkpoint inhibitors, head and neck squamous cell carcinoma, immunotherapy, monoclonal antibodies, osteoradionecrosis",

author = "Victoria Hwang and Eduardo Mendez and Chow, {Laura Q.M.} and Futran, {Neal David} and Peter Andersen and Ryan Li and Vasu Divi and Rodriguez, {Cristina P.}",

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AU - Hwang, Victoria

AU - Mendez, Eduardo

AU - Chow, Laura Q.M.

AU - Futran, Neal David

AU - Andersen, Peter

AU - Li, Ryan

AU - Divi, Vasu

AU - Rodriguez, Cristina P.

PY - 2019/12/1

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AB - Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti–PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 129:E428–E433, 2019.

KW - Head and neck cancer

KW - checkpoint inhibitors

KW - head and neck squamous cell carcinoma

KW - immunotherapy

KW - monoclonal antibodies

KW - osteoradionecrosis

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Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy

Abstract

Keywords

ASJC Scopus subject areas

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