X-ray therapy of experimental malignant melanoma of the hamster eye

Robert P. Burns; Clifford V. Allen; Fredrick T. Fraunfelder

doi:10.1016/0002-9394(69)94080-X

X-ray therapy of experimental malignant melanoma of the hamster eye

Robert P. Burns, Clifford V. Allen, Fredrick T. Fraunfelder

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

There has been wide-spread disagreement about the effect of radiation in malignant melanoma. Therefore, the value of orthovoltage X-ray therapy to the eye of hamsters inoculated with five strains of malignant melanoma has been tested in controlled experiments. Tumor size and survival time were measured. X-ray therapy retarded melanoma growth at times. With some cell lines, X-ray therapy appeared to prolong hamster survival; with others, it did not. Neither X-ray therapy nor surgical enucleation of the eye appeared to be clearly superior.

Original language	English (US)
Pages (from-to)	328-336
Number of pages	9
Journal	American journal of ophthalmology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0002-9394(69)94080-X
State	Published - Aug 1969
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/0002-9394(69)94080-X

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@article{ceb7ab7ddd1646b9a7ef87a4345997a8,

title = "X-ray therapy of experimental malignant melanoma of the hamster eye",

abstract = "There has been wide-spread disagreement about the effect of radiation in malignant melanoma. Therefore, the value of orthovoltage X-ray therapy to the eye of hamsters inoculated with five strains of malignant melanoma has been tested in controlled experiments. Tumor size and survival time were measured. X-ray therapy retarded melanoma growth at times. With some cell lines, X-ray therapy appeared to prolong hamster survival; with others, it did not. Neither X-ray therapy nor surgical enucleation of the eye appeared to be clearly superior.",

author = "Burns, {Robert P.} and Allen, {Clifford V.} and Fraunfelder, {Fredrick T.}",

note = "Funding Information: From the Departments of Ophthalmology and Radiotherapy, University of Oregon Medical School. This study was aided in part by a grant from the American Cancer Society and Grants NBO-5770-03 and NBS042 from the National Institutes of Health.",

year = "1969",

month = aug,

doi = "10.1016/0002-9394(69)94080-X",

language = "English (US)",

volume = "68",

pages = "328--336",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

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T1 - X-ray therapy of experimental malignant melanoma of the hamster eye

AU - Burns, Robert P.

AU - Allen, Clifford V.

AU - Fraunfelder, Fredrick T.

N1 - Funding Information: From the Departments of Ophthalmology and Radiotherapy, University of Oregon Medical School. This study was aided in part by a grant from the American Cancer Society and Grants NBO-5770-03 and NBS042 from the National Institutes of Health.

PY - 1969/8

Y1 - 1969/8

N2 - There has been wide-spread disagreement about the effect of radiation in malignant melanoma. Therefore, the value of orthovoltage X-ray therapy to the eye of hamsters inoculated with five strains of malignant melanoma has been tested in controlled experiments. Tumor size and survival time were measured. X-ray therapy retarded melanoma growth at times. With some cell lines, X-ray therapy appeared to prolong hamster survival; with others, it did not. Neither X-ray therapy nor surgical enucleation of the eye appeared to be clearly superior.

AB - There has been wide-spread disagreement about the effect of radiation in malignant melanoma. Therefore, the value of orthovoltage X-ray therapy to the eye of hamsters inoculated with five strains of malignant melanoma has been tested in controlled experiments. Tumor size and survival time were measured. X-ray therapy retarded melanoma growth at times. With some cell lines, X-ray therapy appeared to prolong hamster survival; with others, it did not. Neither X-ray therapy nor surgical enucleation of the eye appeared to be clearly superior.

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JF - American journal of ophthalmology

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ER -

X-ray therapy of experimental malignant melanoma of the hamster eye

Abstract

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