YAPping about differentiation therapy in muscle cancer

Matthew N. Svalina, Charles Keller

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. In this issue of Cancer Cell, Tremblay and colleagues implicate YAP1 and the Hippo signaling pathway in the maintenance of differentiation-arrested and proliferative phenotypes for embryonal rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)154-155
Number of pages2
JournalCancer Cell
Issue number2
StatePublished - Aug 11 2014
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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