@inproceedings{e7a5a314249f422cabee033753d1bbc0,
title = "ZFP57 and the targeted maintenance of postfertilization genomic imprints",
abstract = "Epigenetic modifications play an important role in modulating genome function. In mammals, inappropriate epigenetic states can cause embryonic lethality and various acquired and inherited diseases; hence, it is important to understand how such states are formed and maintained in particular genomic contexts. Genomic imprinting is a process in which epigenetic states provide a sustained memory of parental origin and cause gene expression/repression from only one of the two parental chromosomes. Genomic imprinting is therefore a valuable model to decipher the principles and processes associated with the targeting and maintenance of epigenetic states in general. Kr{\"u}ppel-associated box zinc finger proteins (KRAB-ZFPs) are proteins that have the potential to mediate this. ZFP57, one of the best characterized proteins in this family, has been shown to target and maintain epigenetic states at imprinting control regions after fertilization. Its role in imprinting through the use of ZFP57 mutants in mouse and the wider implications of KRAB-ZFPs for the targeted maintenance of epigenetic states are discussed here.",
author = "Nozomi Takahashi and Dionne Gray and Ruslan Strogantsev and Angela Noon and Celia Delahaye and Skarnes, {William C.} and Tate, {Peri H.} and Ferguson-Smith, {Anne C.}",
note = "Publisher Copyright: {\textcopyright} 2015 Cold Spring Harbor Laboratory Press.; 21st Century Genetics Genes at Work, 2015 ; Conference date: 26-05-2015 Through 31-05-2015",
year = "2016",
doi = "10.1101/sqb.2015.80.027466",
language = "English (US)",
isbn = "9781621821472",
series = "Cold Spring Harbor Symposia on Quantitative Biology",
publisher = "Cold Spring Harbor Laboratory Press",
pages = "177--187",
editor = "Terri Grodzicker and Bruce Stillman and David Stewart",
booktitle = "21st Century Genetics Genes at Work, 2015",
address = "United States",
}