β-Adrenergic control of atrial natriuretic factor secretion from dispersed rat atrial myocytes

Daniel M. Gibbs

doi:10.1016/0167-0115(87)90076-0

β-Adrenergic control of atrial natriuretic factor secretion from dispersed rat atrial myocytes

Daniel M. Gibbs

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Adrenergic control of atrial natriuretic factor (ANF) secretion was studied using perifused, dispersed atrial myocytes. ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the β-adrenergic agonist isoproterenol (ISO). The response to EPI was completely blocked by equimolar propranolol but not by phenoxybenzamine suggesting that, at least in this system, the adrenergic control of ANF secretion is mediated by β-adrenergic receptors.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	Regulatory Peptides
Volume	19
Issue number	1-2
DOIs	https://doi.org/10.1016/0167-0115(87)90076-0
State	Published - Oct 1987
Externally published	Yes

Keywords

Adrenergic receptor
Atrial natriuretic factor
Epinephrine

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(87)90076-0

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title = "β-Adrenergic control of atrial natriuretic factor secretion from dispersed rat atrial myocytes",

abstract = "Adrenergic control of atrial natriuretic factor (ANF) secretion was studied using perifused, dispersed atrial myocytes. ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the β-adrenergic agonist isoproterenol (ISO). The response to EPI was completely blocked by equimolar propranolol but not by phenoxybenzamine suggesting that, at least in this system, the adrenergic control of ANF secretion is mediated by β-adrenergic receptors.",

keywords = "Adrenergic receptor, Atrial natriuretic factor, Epinephrine",

author = "Gibbs, {Daniel M.}",

note = "Funding Information: This work was supported by Office ooff NNaavv{\~a} l",

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N1 - Funding Information: This work was supported by Office ooff NNaavvã l

PY - 1987/10

Y1 - 1987/10

N2 - Adrenergic control of atrial natriuretic factor (ANF) secretion was studied using perifused, dispersed atrial myocytes. ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the β-adrenergic agonist isoproterenol (ISO). The response to EPI was completely blocked by equimolar propranolol but not by phenoxybenzamine suggesting that, at least in this system, the adrenergic control of ANF secretion is mediated by β-adrenergic receptors.

AB - Adrenergic control of atrial natriuretic factor (ANF) secretion was studied using perifused, dispersed atrial myocytes. ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the β-adrenergic agonist isoproterenol (ISO). The response to EPI was completely blocked by equimolar propranolol but not by phenoxybenzamine suggesting that, at least in this system, the adrenergic control of ANF secretion is mediated by β-adrenergic receptors.

KW - Adrenergic receptor

KW - Atrial natriuretic factor

KW - Epinephrine

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ER -

β-Adrenergic control of atrial natriuretic factor secretion from dispersed rat atrial myocytes

Abstract

Keywords

ASJC Scopus subject areas

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