A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia

Matthew D. Files, Joseph A. Zenel, Laurie B. Armsby, Stephen M. Langley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We present an 8-year-old male with Loeffler endocarditis and acute lymphoblastic leukemia with hypereosinophilia (ALL/Eo) who initially presented with a 3-month history of peripheral eosinophilia thought to be due to visceral larval migrans. Despite treatment for Toxocara, his leukocytosis persisted and he developed mitral valve insufficiency and congestive heart failure. Myocardial biopsy revealed fibrosis and thrombus formation indicative of Loeffler endocarditis, and a peripheral smear showed pre-B-cell acute lymphoid leukemia. This unique case highlights a rare, yet serious sequella of prolonged eosinophilia.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalPediatric Cardiology
Issue number4
StatePublished - May 1 2009


  • Congestive heart failure
  • Eosinophilia
  • Loeffler endocarditis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine


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