TY - JOUR
T1 - A Closer Look at Practice Effects in Mild Cognitive Impairment and Alzheimer’s Disease
AU - Duff, Kevin
AU - Dixon, Ava
AU - Embree, Lindsay
N1 - Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press. All rights reserved.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Practice effects have become a potentially important variable regarding the diagnosis, prognosis, and treatment recommendations in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, the understanding of these short-term changes in test scores remains unclear. The current observational study sought to examine variables that influence the magnitude of short-term practice effects in MCI and AD, including demographic information, cognitive performance, daily functioning, and medical comorbidities. One hundred sixty-six older adults classified as cognitively intact, amnestic MCI, or mild AD were tested twice across 1 week with a brief battery of neuropsychological tests. Correlational and regression analyses examined the relationship of practice effects with demographic and clinical variables. Results indicated that practice effects were minimally related to demographic variables and medical comorbidities, but they were significantly related to cognitive variables, depressive symptoms, and daily functioning. These findings expand our understanding of practice effects in MCI and AD, and they may allow a better appreciation of how they could affect clinical care and research.
AB - Practice effects have become a potentially important variable regarding the diagnosis, prognosis, and treatment recommendations in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, the understanding of these short-term changes in test scores remains unclear. The current observational study sought to examine variables that influence the magnitude of short-term practice effects in MCI and AD, including demographic information, cognitive performance, daily functioning, and medical comorbidities. One hundred sixty-six older adults classified as cognitively intact, amnestic MCI, or mild AD were tested twice across 1 week with a brief battery of neuropsychological tests. Correlational and regression analyses examined the relationship of practice effects with demographic and clinical variables. Results indicated that practice effects were minimally related to demographic variables and medical comorbidities, but they were significantly related to cognitive variables, depressive symptoms, and daily functioning. These findings expand our understanding of practice effects in MCI and AD, and they may allow a better appreciation of how they could affect clinical care and research.
KW - Alzheimer’s disease
KW - Mild cognitive impairment
KW - Practice effects
UR - http://www.scopus.com/inward/record.url?scp=85183126983&partnerID=8YFLogxK
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U2 - 10.1093/arclin/acad046
DO - 10.1093/arclin/acad046
M3 - Article
C2 - 37323010
AN - SCOPUS:85183126983
SN - 0887-6177
VL - 39
SP - 1
EP - 10
JO - Archives of Clinical Neuropsychology
JF - Archives of Clinical Neuropsychology
IS - 1
ER -