TY - JOUR
T1 - A combination of 670 nm and 810 nm diode lasers for wound healing acceleration in diabetic rats
AU - Jahangiri Noudeh, Younes
AU - Shabani, Mohammad
AU - Vatankhah, Nasibeh
AU - Hashemian, Seyyed Jafar
AU - Akbari, Karim
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Objectives: To study the effects of the combination of 670 nm and 810 nm diode lasers on diabetic wound healing parameters in rats. Background: An alternative to traditional treatment modalities for diabetic ulcers is low-level laser therapy (LLLT). A number of published studies demonstrate the beneficial effects of LLLT, although several other studies also exist which indicate results to the contrary. Methods: Four groups were present in our study: Diabetic-laser (n = 5), Diabetic-control (n = 4), Nondiabetic-laser (n = 5) and Nondiabetic-control (n = 5) groups. Two intervention (laser) groups underwent low level laser therapy using 670 nm diode laser (500 mW, 10 J, 48 s) in the wound context, and 810 nm diode laser (250 mW, 12 J, 50 s) to the wound margins. The wound area was measured using computer software after digital microscopic photography on days 0, 3, 6, 9, 12, 15, 20, and 24. Results: There were no statistically significant differences between the diabetic and non-diabetic groups in the wound area, percentage of open wound area, and wound healing rate throughout the repeated measurements of the study. After seven days of low level laser therapy in the non-diabetic group, urine excretion was significantly increased in comparison with the control group. Conclusion: Overall, our study showed results of measured wound healing parameters that were not significantly different in the LLLT group compared with the control group. The urine volume increase in non-diabetic rats after LLLT was an incidental observation that warrants future study.
AB - Objectives: To study the effects of the combination of 670 nm and 810 nm diode lasers on diabetic wound healing parameters in rats. Background: An alternative to traditional treatment modalities for diabetic ulcers is low-level laser therapy (LLLT). A number of published studies demonstrate the beneficial effects of LLLT, although several other studies also exist which indicate results to the contrary. Methods: Four groups were present in our study: Diabetic-laser (n = 5), Diabetic-control (n = 4), Nondiabetic-laser (n = 5) and Nondiabetic-control (n = 5) groups. Two intervention (laser) groups underwent low level laser therapy using 670 nm diode laser (500 mW, 10 J, 48 s) in the wound context, and 810 nm diode laser (250 mW, 12 J, 50 s) to the wound margins. The wound area was measured using computer software after digital microscopic photography on days 0, 3, 6, 9, 12, 15, 20, and 24. Results: There were no statistically significant differences between the diabetic and non-diabetic groups in the wound area, percentage of open wound area, and wound healing rate throughout the repeated measurements of the study. After seven days of low level laser therapy in the non-diabetic group, urine excretion was significantly increased in comparison with the control group. Conclusion: Overall, our study showed results of measured wound healing parameters that were not significantly different in the LLLT group compared with the control group. The urine volume increase in non-diabetic rats after LLLT was an incidental observation that warrants future study.
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U2 - 10.1089/pho.2009.2634
DO - 10.1089/pho.2009.2634
M3 - Article
C2 - 20961229
AN - SCOPUS:78751671069
SN - 1549-5418
VL - 28
SP - 621
EP - 627
JO - Journal of Clinical Laser Medicine and Surgery
JF - Journal of Clinical Laser Medicine and Surgery
IS - 5
ER -