TY - JOUR
T1 - A comparative study of cardiac dysautonomia in autosomal dominant spinocerebellar ataxias and idiopathic sporadic ataxias
AU - Netravathi, M.
AU - Sathyaprabha, T. N.
AU - Jayalaxmi, K.
AU - Datta, P.
AU - Nirmala, M.
AU - Pal, P. K.
PY - 2009/9
Y1 - 2009/9
N2 - Comparative evaluation of cardiac dysautonomia in spinocerebellar ataxias (SCA) and idiopathic sporadic ataxias (IA) not fulfilling the criteria of multiple system atrophy. Material and methods - Cardiac autonomic functions were evaluated in 14 SCA (SCA1 = 6, SCA2 = 5 and SCA3 = 3) and 10 IA patients, comparable for age, age at onset, duration and severity of illness. The results were categorized as early, definitive, or severe autonomic involvement (EI, DI and SI respectively) based on the degree of abnormalities on tests of parasympathetic and sympathetic pathways. Results - Cardiac autonomic dysfunction was present in all (EI = 25.0%, DI = 41.7% and SI = 33.3%), parasympathetic dysfunction being an early feature. SI was most often present in SCA3 (100%), followed by those with SCA1 (66.7%), and SCA2 (20%) and none in IA. Conclusions - Cardiac dysautonomia was common in both SCA and IA, although the severity was greater in SCA. Among SCAs, the severity was greatest in SCA3, followed by SCA2 and least in SCA1.
AB - Comparative evaluation of cardiac dysautonomia in spinocerebellar ataxias (SCA) and idiopathic sporadic ataxias (IA) not fulfilling the criteria of multiple system atrophy. Material and methods - Cardiac autonomic functions were evaluated in 14 SCA (SCA1 = 6, SCA2 = 5 and SCA3 = 3) and 10 IA patients, comparable for age, age at onset, duration and severity of illness. The results were categorized as early, definitive, or severe autonomic involvement (EI, DI and SI respectively) based on the degree of abnormalities on tests of parasympathetic and sympathetic pathways. Results - Cardiac autonomic dysfunction was present in all (EI = 25.0%, DI = 41.7% and SI = 33.3%), parasympathetic dysfunction being an early feature. SI was most often present in SCA3 (100%), followed by those with SCA1 (66.7%), and SCA2 (20%) and none in IA. Conclusions - Cardiac dysautonomia was common in both SCA and IA, although the severity was greater in SCA. Among SCAs, the severity was greatest in SCA3, followed by SCA2 and least in SCA1.
KW - Autonomic function
KW - Cardiac dysautonomia
KW - Idiopathic ataxia
KW - Spinocerebellar ataxia
UR - http://www.scopus.com/inward/record.url?scp=69249162068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69249162068&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0404.2008.01144.x
DO - 10.1111/j.1600-0404.2008.01144.x
M3 - Article
C2 - 19178387
AN - SCOPUS:69249162068
SN - 0001-6314
VL - 120
SP - 204
EP - 209
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 3
ER -