TY - JOUR
T1 - A comparative study of microvessel density in squamous cell carcinoma of the oral cavity and lip
AU - Oliveira-Neto, Helenisa Helena
AU - Gleber-Netto, Frederico Omar
AU - De Sousa, Sílvia Ferreira
AU - França, Cristiane Miranda
AU - Aguiar, Maria Cássia Ferreira
AU - Silva, Tarcília Aparecida
AU - Batista, Aline Carvalho
N1 - Funding Information:
This work was supported by grants from the CNPq (Process n. 470951/2009-5 ).
PY - 2012/3
Y1 - 2012/3
N2 - Objectives. The objective of this study was to comparatively evaluate the density of lymphatic vessels (LVD) and neoformed microvessels (NMVD) in squamous cell carcinoma of the oral cavity (OCSCC) and lip (LSCC). Association between LVD/NMVD and vascular endothelial growth factor (VEGF)-A/-C was also assessed. Study Design. OCSCC and LSCC were compared with regard to immunoexpression of LVD, NMVD, and vascular endothelial growth factor-A (VEGF)-A/-C. Association between VEGF-A/-C with vascularity was also assessed. Statistical analyses were performed using t test, Pearson χ2, and Mann-Whitney tests. Statistical significance was accepted at P less than .05. Results. The NMVD and VEGF-C expressions were significantly higher in OCSCC compared with LSCC. NMVD was associated with VEGF-C in OCSCC, but not in LSCC. Conclusions. Differences in NMVD and VEGF-C were found between OCSCC and LSCC. Positive association between VEGFC and NMVD was observed in OCSCC, but not in LSCC, which may be one of the contributing factors that account for the distinctive clinical-biological behavior of these lesions.
AB - Objectives. The objective of this study was to comparatively evaluate the density of lymphatic vessels (LVD) and neoformed microvessels (NMVD) in squamous cell carcinoma of the oral cavity (OCSCC) and lip (LSCC). Association between LVD/NMVD and vascular endothelial growth factor (VEGF)-A/-C was also assessed. Study Design. OCSCC and LSCC were compared with regard to immunoexpression of LVD, NMVD, and vascular endothelial growth factor-A (VEGF)-A/-C. Association between VEGF-A/-C with vascularity was also assessed. Statistical analyses were performed using t test, Pearson χ2, and Mann-Whitney tests. Statistical significance was accepted at P less than .05. Results. The NMVD and VEGF-C expressions were significantly higher in OCSCC compared with LSCC. NMVD was associated with VEGF-C in OCSCC, but not in LSCC. Conclusions. Differences in NMVD and VEGF-C were found between OCSCC and LSCC. Positive association between VEGFC and NMVD was observed in OCSCC, but not in LSCC, which may be one of the contributing factors that account for the distinctive clinical-biological behavior of these lesions.
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U2 - 10.1016/j.tripleo.2011.08.010
DO - 10.1016/j.tripleo.2011.08.010
M3 - Article
C2 - 22669145
AN - SCOPUS:84862540118
SN - 2212-4403
VL - 113
SP - 391
EP - 398
JO - Oral surgery, oral medicine, oral pathology and oral radiology
JF - Oral surgery, oral medicine, oral pathology and oral radiology
IS - 3
ER -