TY - JOUR
T1 - A low-fat diet improves fatigue in multiple sclerosis
T2 - Results from a randomized controlled trial
AU - Chase, Emma
AU - Chen, Vicky
AU - Martin, Kayla
AU - Lane, Michael
AU - Wooliscroft, Lindsey
AU - Adams, Claire
AU - Rice, Jessica
AU - Silbermann, Elizabeth
AU - Hollen, Christopher
AU - Fryman, Allison
AU - Purnell, Jonathan Q.
AU - Vong, Carly
AU - Orban, Anna
AU - Horgan, Angela
AU - Khan, Akram
AU - Srikanth, Priya
AU - Yadav, Vijayshree
N1 - Publisher Copyright:
© The Author(s), 2023.
PY - 2023/11
Y1 - 2023/11
N2 - Background: Fatigue can be a disabling multiple sclerosis (MS) symptom with no effective treatment options. Objective: Determine whether a low-fat diet improves fatigue in people with MS (PwMS). Methods: We conducted a 16-week randomized controlled trial (RCT) and allocated PwMS to a low-fat diet (active, total daily fat calories not exceeding 20%) or wait-list (control) group. Subjects underwent 2 weeks of baseline diet data collection (24-hour diet recalls (24HDRs)), followed by randomization. The active group received 2 weeks of nutrition counseling and underwent a 12-week low-fat diet intervention. One set of three 24HDRs at baseline and week 16 were collected. We administered a food frequency questionnaire (FFQ) and Modified Fatigue Impact Scale (MFIS) every 4 weeks. The control group continued their pre-study diet and received diet training during the study completion. Results: We recruited 39 PwMS (20—active; 19—control). The active group decreased their daily caloric intake by 11% (95% confidence interval (CI): −18.5%, −3.0%) and the mean MFIS by 4.0 (95% CI: −12.0, 4.0) compared to the control (intent-to-treat). Sensitivity analysis strengthened the association with a mean MFIS difference of −13.9 (95% CI: −20.7, −7.2). Conclusions: We demonstrated a significant reduction in fatigue with a low-fat dietary intervention in PwMS.
AB - Background: Fatigue can be a disabling multiple sclerosis (MS) symptom with no effective treatment options. Objective: Determine whether a low-fat diet improves fatigue in people with MS (PwMS). Methods: We conducted a 16-week randomized controlled trial (RCT) and allocated PwMS to a low-fat diet (active, total daily fat calories not exceeding 20%) or wait-list (control) group. Subjects underwent 2 weeks of baseline diet data collection (24-hour diet recalls (24HDRs)), followed by randomization. The active group received 2 weeks of nutrition counseling and underwent a 12-week low-fat diet intervention. One set of three 24HDRs at baseline and week 16 were collected. We administered a food frequency questionnaire (FFQ) and Modified Fatigue Impact Scale (MFIS) every 4 weeks. The control group continued their pre-study diet and received diet training during the study completion. Results: We recruited 39 PwMS (20—active; 19—control). The active group decreased their daily caloric intake by 11% (95% confidence interval (CI): −18.5%, −3.0%) and the mean MFIS by 4.0 (95% CI: −12.0, 4.0) compared to the control (intent-to-treat). Sensitivity analysis strengthened the association with a mean MFIS difference of −13.9 (95% CI: −20.7, −7.2). Conclusions: We demonstrated a significant reduction in fatigue with a low-fat dietary intervention in PwMS.
KW - Multiple sclerosis
KW - actigraphy
KW - clinical trial
KW - fatigue
KW - low-fat diet
KW - randomized controlled trial
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U2 - 10.1177/13524585231208330
DO - 10.1177/13524585231208330
M3 - Article
C2 - 37941305
AN - SCOPUS:85176464958
SN - 1352-4585
VL - 29
SP - 1659
EP - 1675
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 13
ER -