A mitotic function for Src?

Sara A. Courtneidge, Stefano Fumagalli

Research output: Contribution to journalComment/debatepeer-review

41 Scopus citations


During mitosis, the activity of the c-Src protein tyrosine kinase increases. The tyrosine phosphorylation of a 68 kDa protein (Sam68) also increases at this time, and recent studies have shown that Src and Sam68 interact. Sam68 is highly related to p62, a RasGAP-associated protein, and has homology to RNA-binding proteins. The relationship between p62 and Sam68, and their roles in Src signalling, need to be clarified, but these findings suggest that Src may participate in regulating RNA processing during the cell cycle.

Original languageEnglish (US)
Pages (from-to)345-347
Number of pages3
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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