@article{2eae58c00964499493a2516cb434fd32,
title = "A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines",
abstract = "Factors that impact the reproducibility of experimental data are poorly understood. Five NIH-LINCS centers performed the same set of drug-response measurements and compared results. Technical and biological variables that impact precision and reproducibility and are also sensitive to biological context were the most problematic.",
keywords = "cancer drugs, cell line, dose response, high[HYPHEN]throughput, microscopy, oncology, pharmacology, reproducibility, screening",
author = "{LINCS Consortium} and Mario Niepel and Marc Hafner and Mills, {Caitlin E.} and Kartik Subramanian and Williams, {Elizabeth H.} and Mirra Chung and Benjamin Gaudio and Barrette, {Anne Marie} and Stern, {Alan D.} and Bin Hu and Korkola, {James E.} and Shamu, {Caroline E.} and Gomathi Jayaraman and Azeloglu, {Evren U.} and Ravi Iyengar and Sobie, {Eric A.} and Mills, {Gordon B.} and Tiera Liby and Jaffe, {Jacob D.} and Maria Alimova and Desiree Davison and Xiaodong Lu and Golub, {Todd R.} and Aravind Subramanian and Brandon Shelley and Svendsen, {Clive N.} and Avi Ma'ayan and Mario Medvedovic and Gray, {Joe W.} and Birtwistle, {Marc R.} and Heiser, {Laura M.} and Sorger, {Peter K.}",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = jul,
day = "24",
doi = "10.1016/j.cels.2019.06.005",
language = "English (US)",
volume = "9",
pages = "35--48.e5",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "1",
}