A new synthesis of the labeling precursor for [18F]- fluoromisonidazole

Tom C.H. Adamsen, John R. Grierson, Kenneth A. Krohn

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


[18F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [ 18F]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%.

Original languageEnglish (US)
Pages (from-to)923-927
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number12
StatePublished - Oct 30 2005
Externally publishedYes


  • Fluorine-18
  • Hypoxia
  • Misonidazole
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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