A novel use of the NeuroBlate SideFire probe for minimally invasive disconnection of a hypothalamic hamartoma in a child with gelastic seizures

James M. Wright; Michael D. Staudt; Andrea Alonso; Jonathan P. Miller; Andrew E. Sloan

doi:10.3171/2017.9.PEDS1747

A novel use of the NeuroBlate SideFire probe for minimally invasive disconnection of a hypothalamic hamartoma in a child with gelastic seizures

James M. Wright, Michael D. Staudt, Andrea Alonso, Jonathan P. Miller, Andrew E. Sloan

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The authors describe the case of a 22-month-old boy who presented with gelastic seizures and developmental delay. Magnetic resonance imaging and video-electroencephalography monitoring revealed a primarily intraventricular hypothalamic hamartoma and gelastic seizures occurring 20-30 times daily. The patient was treated with various regimens of antiepileptic medications for 16 months, but the seizures remained medically intractable. At 3 years of age, he underwent stereotactic laser ablation with an aim of disconnection of the lesion. The procedure was performed with the NeuroBlate SideFire probe. To the authors' knowledge, this is the first reported use of this technology for this procedure and serves as proof of concept. There were no perioperative complications, and 2 years postprocedure, the patient remains seizure free with marked behavioral and cognitive improvements.

Original language	English (US)
Pages (from-to)	302-307
Number of pages	6
Journal	Journal of Neurosurgery: Pediatrics
Volume	21
Issue number	3
DOIs	https://doi.org/10.3171/2017.9.PEDS1747
State	Published - Mar 2018
Externally published	Yes

Keywords

Epilepsy
Gelastic seizure
Hypothalamic hamartoma
Laser-induced thermal therapy
NeuroBlate

ASJC Scopus subject areas

Surgery
Pediatrics, Perinatology, and Child Health
Clinical Neurology

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title = "A novel use of the NeuroBlate SideFire probe for minimally invasive disconnection of a hypothalamic hamartoma in a child with gelastic seizures",

abstract = "The authors describe the case of a 22-month-old boy who presented with gelastic seizures and developmental delay. Magnetic resonance imaging and video-electroencephalography monitoring revealed a primarily intraventricular hypothalamic hamartoma and gelastic seizures occurring 20-30 times daily. The patient was treated with various regimens of antiepileptic medications for 16 months, but the seizures remained medically intractable. At 3 years of age, he underwent stereotactic laser ablation with an aim of disconnection of the lesion. The procedure was performed with the NeuroBlate SideFire probe. To the authors' knowledge, this is the first reported use of this technology for this procedure and serves as proof of concept. There were no perioperative complications, and 2 years postprocedure, the patient remains seizure free with marked behavioral and cognitive improvements.",

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AU - Miller, Jonathan P.

AU - Sloan, Andrew E.

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A novel use of the NeuroBlate SideFire probe for minimally invasive disconnection of a hypothalamic hamartoma in a child with gelastic seizures

Abstract

Keywords

ASJC Scopus subject areas

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