TY - JOUR
T1 - A Pilot Study of Fourier-Domain Optical Coherence Tomography of Retinal Dystrophy Patients
AU - Lim, Jennifer I.
AU - Tan, Ou
AU - Fawzi, Amani A.
AU - Hopkins, J. Jill
AU - Gil-Flamer, John H.
AU - Huang, David
N1 - Funding Information:
This study was supported by the National Eye Institute of the National Institutes of Health R01 EY013516, EY495707, and EY03040, Bethesda, Maryland; Research to Prevent Blindness, New York, New York; Age-related Macular Degeneration Research Fund; and Optovue Inc. Dr Huang has research grants, stock options, consulting relationship, travel support, and potential patent royalty interest in Optovue Inc. Dr Lim has received one honorarium for a lecture discussing the Optovue system. Dr Tan has received grant support from Optovue Inc. Involved in design of study (J.I.L., O.T., A.A.F., J.H.G.-F., D.H.); conduct of study (J.I.L., O.T., A.A.F., J.H.G.-F., D.H.); collection (J.I.L., O.T., A.A.F., J.H.G.-F., D.H.), management (J.I.L., O.T., J.H.G.-F.), analysis (J.I.L., O.T., A.A.F., J.H.G.-F., J.J.H., D.H.), and interpretation of the data (J.I.L., O.T., A.A.F., J.H.G.-F., J.J.H., D.H.); and preparation (J.I.L., O.T.), review (J.I.L., O.T., A.A.F., J.H.G.-F., J.J.H., D.H.), or approval of the manuscript (J.I.L., O.T., A.A.F., J.H.G.-F., J.J.H., D.H.). The University of Southern California Institutional Review Board approved the research. Written informed consent was obtained for this study.
PY - 2008/9
Y1 - 2008/9
N2 - Purpose: To characterize the macular anatomy of retinal dystrophy eyes using high-speed, high-resolution, Fourier-domain optical coherence tomography (FD-OCT). Design: Case-control study. Methods: Retinal dystrophy patients and normal age- and gender-matched controls underwent FD-OCT imaging using the RTVue (Optovue Inc, Fremont, California, USA). Vertical and horizontal 8-mm scans of 1024 lines/cross-section were obtained. Based on boundaries manually drawn on computer displays of OCT cross-sections, the thicknesses of the retina, inner retinal layer (IRL), and outer retinal layer (ORL) were averaged over both 5-mm (macular) and 1.5-mm (foveal) regions centered at the fovea. The IRL was the sum of nerve fiber layer (NFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) thicknesses. Total retinal thickness (RT) was measured between the internal limiting membrane (ILM) and the retinal pigment epithelium. ORL thickness was calculated by subtracting IRL thickness from RT. Results: Fourteen patients (three retinitis pigmentosa, two cone-rod degeneration, two Stargardt disease, and seven normal controls) underwent FD-OCT imaging. Mean foveal RT was 271.3 ± 23.3 μm for controls and 158.4 ± 47.1 μm for retinal dystrophy patients (P < .001). Mean macular RT was 292.8 ± 8.1 μm for controls and 199.1 ± 32.6 μm for retinal dystrophy patients (P < .001). Mean macular ORL was 182.9 ± 4.7 μm for controls and 101.3 ± 18.7 μm for retinal dystrophy patients (P < .001); mean macular IRL was 109.9 ± 6.4 μm for controls and 97.9 ± 20.7 μm for retinal dystrophy patients (P = .06). Conclusion: Eyes with retinal dystrophy had a small (11%) decrease in macular IRL and severe (45%) decrease in macular ORL compared to normal controls.
AB - Purpose: To characterize the macular anatomy of retinal dystrophy eyes using high-speed, high-resolution, Fourier-domain optical coherence tomography (FD-OCT). Design: Case-control study. Methods: Retinal dystrophy patients and normal age- and gender-matched controls underwent FD-OCT imaging using the RTVue (Optovue Inc, Fremont, California, USA). Vertical and horizontal 8-mm scans of 1024 lines/cross-section were obtained. Based on boundaries manually drawn on computer displays of OCT cross-sections, the thicknesses of the retina, inner retinal layer (IRL), and outer retinal layer (ORL) were averaged over both 5-mm (macular) and 1.5-mm (foveal) regions centered at the fovea. The IRL was the sum of nerve fiber layer (NFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) thicknesses. Total retinal thickness (RT) was measured between the internal limiting membrane (ILM) and the retinal pigment epithelium. ORL thickness was calculated by subtracting IRL thickness from RT. Results: Fourteen patients (three retinitis pigmentosa, two cone-rod degeneration, two Stargardt disease, and seven normal controls) underwent FD-OCT imaging. Mean foveal RT was 271.3 ± 23.3 μm for controls and 158.4 ± 47.1 μm for retinal dystrophy patients (P < .001). Mean macular RT was 292.8 ± 8.1 μm for controls and 199.1 ± 32.6 μm for retinal dystrophy patients (P < .001). Mean macular ORL was 182.9 ± 4.7 μm for controls and 101.3 ± 18.7 μm for retinal dystrophy patients (P < .001); mean macular IRL was 109.9 ± 6.4 μm for controls and 97.9 ± 20.7 μm for retinal dystrophy patients (P = .06). Conclusion: Eyes with retinal dystrophy had a small (11%) decrease in macular IRL and severe (45%) decrease in macular ORL compared to normal controls.
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U2 - 10.1016/j.ajo.2008.05.018
DO - 10.1016/j.ajo.2008.05.018
M3 - Article
C2 - 18635153
AN - SCOPUS:49749107861
SN - 0002-9394
VL - 146
SP - 417-426.e2
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 3
ER -