A randomized trial of compression first or analyze first strategies in patients with out-of-hospital cardiac arrest: Results from an Asian community

Matthew Huei Ming Ma, Wen Chu Chiang, Patrick Chow In Ko, Chi Wei Yang, Hui Chi Wang, Shey Ying Chen, Wei Tien Chang, Chien Hwa Huang, Hao Chang Chou, Mei Shu Lai, Kuo Long Chien, Bin Chou Lee, Chien Hwa Hwang, Yao Cheng Wang, Guan Hwa Hsiung, Ying Wen Hsiao, Anna Marie Chang, Wen Jone Chen, Shyr Chyr Chen

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: It is still under debate whether a period of cardiopulmonary resuscitation should be performed prior to rhythm analysis for defibrillation for out of hospital cardiac arrests (OHCA). This study compared outcomes of OHCA treated by " compression first" (CF) versus " analyze first" (AF) strategies in an Asian community with low rates of shockable rhythms. Methods: This randomized trial was conducted in Taipei City between February 2008 and December 2009. Dispatches of suspected OHCA that activated advanced life support teams were randomized into the CF and AF strategies. Patients assigned to CF strategy received 10 cycles of CPR prior to analysis by automatic external defibrillator. The primary outcome was sustained (>2. h) return of spontaneous circulation (ROSC) and secondary outcome was survival to hospital discharge. Results: We included 289 cases in the final analysis after exclusion by pre-specified criteria, 141 were allocated to CF strategy and 148 to AF strategy. Baseline characteristics were similar. Thirty-seven (26.2%) of those receiving CF strategy and 49 (33.1%) of the AF strategy achieved sustained ROSC (. p=. 0.25). In a post-hoc analysis of patients who achieved ROSC, those that received CF strategy were more likely to be discharged alive from the hospital (16/37. =. 43.2% vs. 11/49. =. 22.4%, . p=. 0.02). Conclusion: In this study population of low rates of shockable rhythms, there was no difference in ROSC for CF or AF strategies. Considering the EMS operation situations, a period of paramedic-administered CPR for up to 10 cycles prior to rhythm analysis could be a feasible strategy in this community.

Original languageEnglish (US)
Pages (from-to)806-812
Number of pages7
Issue number7
StatePublished - Jul 2012
Externally publishedYes


  • Automatic external defibrillator
  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Emergency medical services systems
  • Shockable rhythm
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine


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