Abstract
In cancer, Wnt/β-catenin signaling is ubiquitously referred to as an "oncogenic" pathway that promotes tumor progression. This review examines how the regulation and downstream effects of Wnt/β-catenin signaling in cancer varies depending on cellular context, with a focus on malignant melanoma. We emphasize that the cellular homeostasis of Wnt/β-catenin signaling may represent a more appropriate concept than the simplified view of the Wnt/β-catenin pathway as either oncogenic or tumor-suppressing. Ultimately, a more refined understanding of the contextual regulation of Wnt/β-catenin signaling will be essential for addressing if and how therapeutic targeting of this pathway could be leveraged for patient benefit.
Original language | English (US) |
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Pages (from-to) | 314-318 |
Number of pages | 5 |
Journal | Current oncology reports |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2010 |
Externally published | Yes |
Keywords
- Beta-catenin
- Homeostasis
- Melanoma
- Oncogene
- Wnt
ASJC Scopus subject areas
- Oncology