A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

Janet L. Lathey; Jan M. Agosti; Jay A. Nelson; Lawrence Corey; Susan A. Gregory; James H. Morrissey; Thomas S. Edgington; Michael B.A. Oldstone

doi:10.1016/0090-1229(90)90001-7

A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

Janet L. Lathey, Jan M. Agosti, Jay A. Nelson, Lawrence Corey, Susan A. Gregory, James H. Morrissey, Thomas S. Edgington, Michael B.A. Oldstone

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

Original language	English (US)
Pages (from-to)	1-13
Number of pages	13
Journal	Clinical Immunology and Immunopathology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(90)90001-7
State	Published - Jan 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

Access to Document

10.1016/0090-1229(90)90001-7

Cite this

@article{aec84d1a909548c08f9a5e5b794b283f,

title = "A selective defect in tissue factor mRNA expression in monocytes from AIDS patients",

abstract = "Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was {"}normal.{"} TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.",

author = "Lathey, {Janet L.} and Agosti, {Jan M.} and Nelson, {Jay A.} and Lawrence Corey and Gregory, {Susan A.} and Morrissey, {James H.} and Edgington, {Thomas S.} and Oldstone, {Michael B.A.}",

note = "Funding Information: This is Publication Number 5435IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA. This work was supported in part by USPHS Grants NS-12428, NIH HL-16411, AI-07007, AI-24178, and University of California Task Force on AIDS (J.A.N.) and a NIH postdoctoral training award (NS-07078) to J.L.L. This work was done during the tenure of an Established Investigatorship (J.H.M.) from the American Heart Association. J.A.N. is the recipient of a faculty award from the American Cancer Society. The authors wish to thank Tom Cook and Jamie Myer for their technical assistance, and Diane Nolin and Gay Schilling for manuscript preparation.",

year = "1990",

month = jan,

doi = "10.1016/0090-1229(90)90001-7",

language = "English (US)",

volume = "54",

pages = "1--13",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

AU - Lathey, Janet L.

AU - Agosti, Jan M.

AU - Nelson, Jay A.

AU - Corey, Lawrence

AU - Gregory, Susan A.

AU - Morrissey, James H.

AU - Edgington, Thomas S.

AU - Oldstone, Michael B.A.

N1 - Funding Information: This is Publication Number 5435IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA. This work was supported in part by USPHS Grants NS-12428, NIH HL-16411, AI-07007, AI-24178, and University of California Task Force on AIDS (J.A.N.) and a NIH postdoctoral training award (NS-07078) to J.L.L. This work was done during the tenure of an Established Investigatorship (J.H.M.) from the American Heart Association. J.A.N. is the recipient of a faculty award from the American Cancer Society. The authors wish to thank Tom Cook and Jamie Myer for their technical assistance, and Diane Nolin and Gay Schilling for manuscript preparation.

PY - 1990/1

Y1 - 1990/1

N2 - Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

AB - Expression of tumor necrosis factor (TNFα), tissue factor (TF), and interleukin 1-β (IL-1β) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNFα and IL-1β, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

UR - http://www.scopus.com/inward/record.url?scp=0025099006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025099006&partnerID=8YFLogxK

U2 - 10.1016/0090-1229(90)90001-7

DO - 10.1016/0090-1229(90)90001-7

M3 - Article

C2 - 2293902

AN - SCOPUS:0025099006

SN - 1521-6616

VL - 54

SP - 1

EP - 13

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -

A selective defect in tissue factor mRNA expression in monocytes from AIDS patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this