A SNARE required for retrograde transport to the endoplasmic reticulum

Lena Burri, Oleg Varlamov, Claudia A. Doege, Kay Hofmann, Traude Beilharz, James E. Rothman, Thomas H. Söllner, Trevor Lithgow

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-/ike tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.

Original languageEnglish (US)
Pages (from-to)9873-9877
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number17
StatePublished - Aug 19 2003
Externally publishedYes


  • Membrane fusion
  • Secretion
  • Slt1
  • Tail-anchored protein

ASJC Scopus subject areas

  • General


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