AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

William A. Liguore; Jacqueline S. Domire; Dana Button; Yun Wang; Brett D. Dufour; Sathya Srinivasan; Jodi L. McBride

doi:10.1016/j.ymthe.2019.07.017

AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

William A. Liguore, Jacqueline S. Domire, Dana Button, Yun Wang, Brett D. Dufour, Sathya Srinivasan, Jodi L. McBride

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Liguore and colleagues characterize biodistribution of AAV-PHP.B in the rodent and rhesus macaque CNS following intra-CSF and intravascular delivery modalities. Although equal transduction efficiency was seen in mice regardless of delivery route, intra-cisterna magna infusion led to superior transduction efficiency compared with intra-carotid artery infusion in the rhesus macaque CNS.

Original language	English (US)
Pages (from-to)	2018-2037
Number of pages	20
Journal	Molecular Therapy
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.ymthe.2019.07.017
State	Published - Nov 6 2019

Keywords

AAV-PHP.B
AAV9
CNS
adeno-associated virus
brain
gene therapy
gene transfer
mouse
rhesus macaque
viral transduction

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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10.1016/j.ymthe.2019.07.017

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title = "AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice",

abstract = "Liguore and colleagues characterize biodistribution of AAV-PHP.B in the rodent and rhesus macaque CNS following intra-CSF and intravascular delivery modalities. Although equal transduction efficiency was seen in mice regardless of delivery route, intra-cisterna magna infusion led to superior transduction efficiency compared with intra-carotid artery infusion in the rhesus macaque CNS.",

keywords = "AAV-PHP.B, AAV9, CNS, adeno-associated virus, brain, gene therapy, gene transfer, mouse, rhesus macaque, viral transduction",

author = "Liguore, {William A.} and Domire, {Jacqueline S.} and Dana Button and Yun Wang and Dufour, {Brett D.} and Sathya Srinivasan and McBride, {Jodi L.}",

note = "Publisher Copyright: {\textcopyright} 2019 The American Society of Gene and Cell Therapy",

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doi = "10.1016/j.ymthe.2019.07.017",

language = "English (US)",

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T1 - AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

AU - Liguore, William A.

AU - Domire, Jacqueline S.

AU - Button, Dana

AU - Wang, Yun

AU - Dufour, Brett D.

AU - Srinivasan, Sathya

AU - McBride, Jodi L.

PY - 2019/11/6

Y1 - 2019/11/6

N2 - Liguore and colleagues characterize biodistribution of AAV-PHP.B in the rodent and rhesus macaque CNS following intra-CSF and intravascular delivery modalities. Although equal transduction efficiency was seen in mice regardless of delivery route, intra-cisterna magna infusion led to superior transduction efficiency compared with intra-carotid artery infusion in the rhesus macaque CNS.

AB - Liguore and colleagues characterize biodistribution of AAV-PHP.B in the rodent and rhesus macaque CNS following intra-CSF and intravascular delivery modalities. Although equal transduction efficiency was seen in mice regardless of delivery route, intra-cisterna magna infusion led to superior transduction efficiency compared with intra-carotid artery infusion in the rhesus macaque CNS.

KW - AAV-PHP.B

KW - AAV9

KW - CNS

KW - adeno-associated virus

KW - brain

KW - gene therapy

KW - gene transfer

KW - mouse

KW - rhesus macaque

KW - viral transduction

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SN - 1525-0016

VL - 27

SP - 2018

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JO - Molecular Therapy

JF - Molecular Therapy

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ER -

AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

Abstract

Keywords

ASJC Scopus subject areas

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