Abstract
A recent study found high levels of human immunodeficiency virus type 1 (HIV-1) bound to erythrocytes in HIV-1 - infected patients with long-term undetectable plasma HIV-1 loads, potentially representing a novel and important reservoir of HIV-1 infection. To attempt to confirm this finding, we purified erythrocytes from 13 HIV-1 - infected patients with long-term undetectable plasma viral load and depleted contaminating CD3+CD4+ lymphocytes using magnetic beads. HIV-1 load of the purified erythrocyte fraction was <20 copies/mL in 11 of 13 patients and 42 and 52 copies/mL in 2 patients. Contrary to the prior report, therefore, erythrocytes do not represent a novel reservoir of HIV-1 infection in these patients.
Original language | English (US) |
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Pages (from-to) | 587-590 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 196 |
Issue number | 4 |
DOIs | |
State | Published - Aug 15 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases