@article{a0574c46cd444eac99e8da655accbfbd,
title = "Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop",
abstract = "The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: Pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.",
keywords = "chronic pancreatitis, clinical trial design, natural history of chronic pancreatitis, pain in chronic pancreatitis",
author = "Forsmark, {Christopher E.} and Andersen, {Dana K.} and Farrar, {John T.} and Megan Golden and Aida Habtezion and Husain, {Sohail Z.} and Liang Li and Julia Mayerle and Pandol, {Stephen J.} and Aliye Uc and Zixi Zhu and Dhiraj Yadav",
note = "Funding Information: From the *Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL; †Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; ‡Departments of Epidemiology, Neurology, and Anesthesia, University of Pennsylvania Philadelphia, PA; §Mission: Cure, Chicago, IL; ||Department of Medicine, Stanford University Stanford, CA; ¶Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA; #Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX; **Department of Medicine II, Ludwig Maximilians University and Polyklinik, Munich, Germany; ††Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; ‡‡Division of Gastroenterology, Stead Family Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA; and §§Division of Gastroenterology, University of Pittsburgh, Pittsburgh, PA. Received for publication August 5, 2018; accepted August 28, 2018. Address correspondence to: Christopher E. Forsmark, MD, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Box 100214, 1329 SW 16th St, Suite 5251, Gainesville, FL 32610 (e‐mail: chris.forsmark@medicine.ufl.edu). A.U. is a member of the American Board of Pediatrics, Pediatric Gastroenterology Subboard. The other authors declare no conflict of interest. This publication was supported by the National Cancer Institute and National Institutes of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108320 (to C.E.F.), U01DK108300 (to A.H.), U01DK108334 (to S.Z.H.), U01DK108314 (to S.J.P.), U01DK108334 (to A.U.), and U01DK108306 (to D.Y.) within RFA-DK-14-027, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001174 Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
month = nov,
day = "1",
doi = "10.1097/MPA.0000000000001174",
language = "English (US)",
volume = "47",
pages = "1200--1207",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "10",
}