In vivo 19 fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain-plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD=1.0) (95% confidence interval=1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
|Original language||English (US)|
|Number of pages||3|
|Journal||American Journal of Psychiatry|
|State||Published - 1992|
ASJC Scopus subject areas
- Psychiatry and Mental health