Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

Perry F. Renshaw, Alexander R. Guimaraes, Maurizio Fava, Jerrold F. Rosenbaum, Justin D. Pearlman, James G. Flood, Patricia R. Puopolo, Katherine Clancy, R. Gilberto Gonzalez

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


In vivo 19 fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain-plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD=1.0) (95% confidence interval=1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.

Original languageEnglish (US)
Pages (from-to)1592-1594
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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