TY - JOUR
T1 - Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration
AU - Renshaw, Perry F.
AU - Guimaraes, Alexander R.
AU - Fava, Maurizio
AU - Rosenbaum, Jerrold F.
AU - Pearlman, Justin D.
AU - Flood, James G.
AU - Puopolo, Patricia R.
AU - Clancy, Katherine
AU - Gilberto Gonzalez, R.
PY - 1992
Y1 - 1992
N2 - In vivo 19 fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain-plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD=1.0) (95% confidence interval=1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
AB - In vivo 19 fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain-plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD=1.0) (95% confidence interval=1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
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M3 - Article
C2 - 1415832
AN - SCOPUS:0026768367
SN - 0002-953X
VL - 149
SP - 1592
EP - 1594
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 11
ER -