Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

E. L. Mora-Blanco; Y. Mishina; E. J. Tillman; Y. J. Cho; C. S. Thom; S. L. Pomeroy; W. Shao; C. W.M. Roberts

doi:10.1038/onc.2013.37

Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

E. L. Mora-Blanco, Y. Mishina, E. J. Tillman, Y. J. Cho, C. S. Thom, S. L. Pomeroy, W. Shao, C. W.M. Roberts

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65 Scopus citations

Abstract

The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.

Original language	English (US)
Pages (from-to)	933-938
Number of pages	6
Journal	Oncogene
Volume	33
Issue number	7
DOIs	https://doi.org/10.1038/onc.2013.37
State	Published - Feb 13 2014
Externally published	Yes

Keywords

Swi/Snf
beta-catenin
chromatin remodeling
epigenetics
tumor suppressor

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/onc.2013.37

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title = "Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5",

abstract = "The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.",

keywords = "Swi/Snf, beta-catenin, chromatin remodeling, epigenetics, tumor suppressor",

author = "Mora-Blanco, {E. L.} and Y. Mishina and Tillman, {E. J.} and Cho, {Y. J.} and Thom, {C. S.} and Pomeroy, {S. L.} and W. Shao and Roberts, {C. W.M.}",

note = "Funding Information: We thank ES McKenna for critical reading of the manuscript and A Lassar for helpful discussions. The in situ probe constructs were generously provided by C Tabin (Harvard Medical School). This work was supported in part by National Cancer Institute, National Institutes of Health Pre-Doctoral NRSA award 1F31CA130553 (ELMB), R01CA113794 (CWMR) and U01-1156106 (Stuart H Orkin). CWM R is a recipient of a Stand Up 2 Cancer Innovative Research Grant. Miles for Mary, The Garrett B Smith Foundation and Cure AT/RT Now provided additional support.",

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AU - Mora-Blanco, E. L.

AU - Mishina, Y.

AU - Tillman, E. J.

AU - Cho, Y. J.

AU - Thom, C. S.

AU - Pomeroy, S. L.

AU - Shao, W.

AU - Roberts, C. W.M.

N1 - Funding Information: We thank ES McKenna for critical reading of the manuscript and A Lassar for helpful discussions. The in situ probe constructs were generously provided by C Tabin (Harvard Medical School). This work was supported in part by National Cancer Institute, National Institutes of Health Pre-Doctoral NRSA award 1F31CA130553 (ELMB), R01CA113794 (CWMR) and U01-1156106 (Stuart H Orkin). CWM R is a recipient of a Stand Up 2 Cancer Innovative Research Grant. Miles for Mary, The Garrett B Smith Foundation and Cure AT/RT Now provided additional support.

PY - 2014/2/13

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AB - The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.

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Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

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Keywords

ASJC Scopus subject areas

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