TY - JOUR
T1 - Active Learning of Contrast Sensitivity to Assess Visual Function in Macula-Off Retinal Detachment
AU - Thomas, Merina
AU - Silverman, Rebecca F.
AU - Vingopoulos, Filippos
AU - Kasetty, Megan
AU - Yu, Gina
AU - Kim, Esther L.
AU - Omari, Amro A.
AU - Joltikov, Katherine A.
AU - Choi, Eun Y.
AU - Kim, Leo A.
AU - Zacks, David N.
AU - Miller, John B.
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Purpose: This work characterizes the contrast sensitivity function (CSF) in patients with successful repair of macula-off rhegmatogenous retinal detachment (RD) using an adaptive computerized contrast testing device. Methods: CSF was prospectively measured in patients with macula-off RD following successful repair and age-matched controls at W.K. Kellogg Eye Center and Massachusetts Eye and Ear using Adaptive Sensory Technology’s Manifold Contrast Vision Meter. Outcome measures included average area under the CSF curve, contrast-sensitivity thresholds (1-18 cycles per degree), and best-corrected visual acuity (BCVA) in RD eyes, fellow eyes, and controls. A subanalysis was performed in eyes with BCVA of 20/30 or better. Results: Twenty-three macula-off RD eyes following repair, fellow healthy eyes, and 45 age-matched control eyes underwent CSF testing. Mean BCVA of the 23 RD eyes was 0.250 logMAR, which was, significantly reduced compared with fellow eyes 0.032 (P <.001) and controls 0.026 (P <.001). There was a statistically significant reduction in average area under the CSF curve in RD eyes compared with fellow eyes (P <.0001) and age-matched controls (z score –0.90, P <.0001) and CSF reduction across all spatial frequencies. In the 15 RD eyes with BCVA of 20/30 or better, the mean CSF was significantly reduced vs fellow eyes (P =.02) and controls (P =.045). Conclusions: CSF in macula-off RD eyes following repair was significantly reduced compared with fellow eyes and age-matched controls. CSF may be a promising visual function end point with applications in clinical practice and future clinical trials.
AB - Purpose: This work characterizes the contrast sensitivity function (CSF) in patients with successful repair of macula-off rhegmatogenous retinal detachment (RD) using an adaptive computerized contrast testing device. Methods: CSF was prospectively measured in patients with macula-off RD following successful repair and age-matched controls at W.K. Kellogg Eye Center and Massachusetts Eye and Ear using Adaptive Sensory Technology’s Manifold Contrast Vision Meter. Outcome measures included average area under the CSF curve, contrast-sensitivity thresholds (1-18 cycles per degree), and best-corrected visual acuity (BCVA) in RD eyes, fellow eyes, and controls. A subanalysis was performed in eyes with BCVA of 20/30 or better. Results: Twenty-three macula-off RD eyes following repair, fellow healthy eyes, and 45 age-matched control eyes underwent CSF testing. Mean BCVA of the 23 RD eyes was 0.250 logMAR, which was, significantly reduced compared with fellow eyes 0.032 (P <.001) and controls 0.026 (P <.001). There was a statistically significant reduction in average area under the CSF curve in RD eyes compared with fellow eyes (P <.0001) and age-matched controls (z score –0.90, P <.0001) and CSF reduction across all spatial frequencies. In the 15 RD eyes with BCVA of 20/30 or better, the mean CSF was significantly reduced vs fellow eyes (P =.02) and controls (P =.045). Conclusions: CSF in macula-off RD eyes following repair was significantly reduced compared with fellow eyes and age-matched controls. CSF may be a promising visual function end point with applications in clinical practice and future clinical trials.
KW - contrast sensitivity function
KW - macula-off retinal detachment
KW - qCSF
KW - visual function
KW - visual function end points
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U2 - 10.1177/2474126420961957
DO - 10.1177/2474126420961957
M3 - Article
AN - SCOPUS:85155585898
SN - 2474-1264
VL - 5
SP - 313
EP - 320
JO - Journal of VitreoRetinal Diseases
JF - Journal of VitreoRetinal Diseases
IS - 4
ER -