TY - JOUR
T1 - Acute Encephalopathy in Siblings
T2 - Reye Syndrome vs Salicylate Intoxication
AU - Rosenfeld, Ron G.
AU - Liebhaber, Myron I.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1976/3
Y1 - 1976/3
N2 - Siblings, aged 9 and 7 years, had simultaneous onset of vomiting, disorientation, ataxia, and coma. Both children had prodromal symptoms of upper respiratory tract infections, and had been treated with large doses of aspirin. Laboratory data showed evidence of hepatocellular dysfunction, with an elevated serum ammonia level in one patient; salicylate levels were 50 and 44 mg/100 ml. The child who died had autopsy evidence of cerebral edema and fatty liver. The difficulty in clinically differentiating Reye syndrome from salicylate intoxication is discussed.
AB - Siblings, aged 9 and 7 years, had simultaneous onset of vomiting, disorientation, ataxia, and coma. Both children had prodromal symptoms of upper respiratory tract infections, and had been treated with large doses of aspirin. Laboratory data showed evidence of hepatocellular dysfunction, with an elevated serum ammonia level in one patient; salicylate levels were 50 and 44 mg/100 ml. The child who died had autopsy evidence of cerebral edema and fatty liver. The difficulty in clinically differentiating Reye syndrome from salicylate intoxication is discussed.
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U2 - 10.1001/archpedi.1976.02120040073014
DO - 10.1001/archpedi.1976.02120040073014
M3 - Article
C2 - 1258838
AN - SCOPUS:0017045287
SN - 0096-8994
VL - 130
SP - 295
EP - 297
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 3
ER -