Acute kidney injury in older adults

Sharon Anderson, Basil Eldadah, Jeffrey B. Halter, William R. Hazzard, Jonathan Himmelfarb, Frances Mc Farland Horne, Paul L. Kimmel, Bruce A. Molitoris, Mahadev Murthy, Ann M. O'Hare, Kenneth E. Schmader, Kevin P. High

Research output: Contribution to journalArticlepeer-review

154 Scopus citations


Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definition and diagnosis of acute kidney injury are based on changes in creatinine, which is an inadequate marker and might identify patients when it is too late. The incidence of acute kidney injury is rising and increases with advancing age, yet clinical studies have been slow to address geriatric issues or the heterogeneity in etiologies, outcomes, or patient preferences among the elderly. Here we examine some of the current literature, identify knowledge gaps, and suggest potential research questions regarding acute kidney injury in older adults. Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
JournalJournal of the American Society of Nephrology
Issue number1
StatePublished - Jan 2011

ASJC Scopus subject areas

  • Nephrology


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