Acute megakaryoblastic leukemia in Down syndrome: Orbital infiltration

Jeffrey L. Olson; Michael J. May; Linda Stork; Nina Kadan; J. Bronwyn Bateman

doi:10.1016/S0002-9394(00)00459-1

Acute megakaryoblastic leukemia in Down syndrome: Orbital infiltration

Jeffrey L. Olson, Michael J. May, Linda Stork, Nina Kadan, J. Bronwyn Bateman

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

PURPOSE: To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome. METHOD: Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits. RESULTS: Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment. CONCLUSIONS: Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome. (C) 2000 by Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	128-130
Number of pages	3
Journal	American journal of ophthalmology
Volume	130
Issue number	1
DOIs	https://doi.org/10.1016/S0002-9394(00)00459-1
State	Published - Jul 2000
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Acute megakaryoblastic leukemia in Down syndrome: Orbital infiltration",

abstract = "PURPOSE: To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome. METHOD: Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits. RESULTS: Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment. CONCLUSIONS: Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome. (C) 2000 by Elsevier Science Inc.",

author = "Olson, {Jeffrey L.} and May, {Michael J.} and Linda Stork and Nina Kadan and Bateman, {J. Bronwyn}",

year = "2000",

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doi = "10.1016/S0002-9394(00)00459-1",

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TY - JOUR

T1 - Acute megakaryoblastic leukemia in Down syndrome

T2 - Orbital infiltration

AU - Olson, Jeffrey L.

AU - May, Michael J.

AU - Stork, Linda

AU - Kadan, Nina

AU - Bateman, J. Bronwyn

PY - 2000/7

Y1 - 2000/7

N2 - PURPOSE: To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome. METHOD: Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits. RESULTS: Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment. CONCLUSIONS: Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome. (C) 2000 by Elsevier Science Inc.

AB - PURPOSE: To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome. METHOD: Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits. RESULTS: Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment. CONCLUSIONS: Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome. (C) 2000 by Elsevier Science Inc.

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JO - American journal of ophthalmology

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Acute megakaryoblastic leukemia in Down syndrome: Orbital infiltration

Abstract

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