TY - JOUR
T1 - Acute postnatal exposure to the pentaBDE commercial mixture DE-71 at 5 or 15mg/kg/day does not produce learning or attention deficits in rats
AU - Driscoll, Lori L.
AU - Kaplan, Joshua
AU - Bucuvalas, Eleni
AU - Allen, Hunter
AU - Kraut, Joshua
AU - Fitzpatrick, Jesse
N1 - Funding Information:
We thank the Colorado College for providing funding for this study in the form of Research and Development grants to L.L. Driscoll, a Dean's Summer Research Grant to L.L. Driscoll and E. Bucuvalas, and Venture Grants to J. Kaplan and H. Allen.
PY - 2012/1
Y1 - 2012/1
N2 - Polybrominated diphenyl ethers (PBDEs), flame retardant chemicals added to polymer products, have become ubiquitous in the environment, and they are bioaccumulating in humans and wildlife. Therefore, understanding their biological effects is important for public health. We have previously observed learning deficits in rats exposed to DE-71, a commercial PBDE mixture consisting primarily of pentabrominated diphenyl ethers, at a dose of 30. mg/kg/day from postnatal day (PND) 6 to 12. The purpose of the current study was to determine if this effect could be seen with lower doses of DE-71. Long-Evans rats were administered daily oral doses of corn oil alone or DE-71, 5 or 15. mg/kg/day, dissolved in corn oil, from PND 6 to 12. As young adults, the rats were administered a series of five-choice visual learning and attention tasks. No effects of DE-71 were found on learning, attention, or inhibitory control. Given that developmental DE-71 exposure at similar doses and for shorter time periods has been shown in other laboratories to affect locomotion and hyperactivity, the current results suggest that cognitive functions may not be as sensitive as neuromotor functions to the effects of acute DE-71 exposure.
AB - Polybrominated diphenyl ethers (PBDEs), flame retardant chemicals added to polymer products, have become ubiquitous in the environment, and they are bioaccumulating in humans and wildlife. Therefore, understanding their biological effects is important for public health. We have previously observed learning deficits in rats exposed to DE-71, a commercial PBDE mixture consisting primarily of pentabrominated diphenyl ethers, at a dose of 30. mg/kg/day from postnatal day (PND) 6 to 12. The purpose of the current study was to determine if this effect could be seen with lower doses of DE-71. Long-Evans rats were administered daily oral doses of corn oil alone or DE-71, 5 or 15. mg/kg/day, dissolved in corn oil, from PND 6 to 12. As young adults, the rats were administered a series of five-choice visual learning and attention tasks. No effects of DE-71 were found on learning, attention, or inhibitory control. Given that developmental DE-71 exposure at similar doses and for shorter time periods has been shown in other laboratories to affect locomotion and hyperactivity, the current results suggest that cognitive functions may not be as sensitive as neuromotor functions to the effects of acute DE-71 exposure.
KW - Attention
KW - Cognition
KW - Learning
KW - Polybrominated diphenyl ethers
KW - Postnatal exposure
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U2 - 10.1016/j.ntt.2011.10.002
DO - 10.1016/j.ntt.2011.10.002
M3 - Article
C2 - 22024237
AN - SCOPUS:82655169369
SN - 0892-0362
VL - 34
SP - 20
EP - 26
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
IS - 1
ER -