TY - JOUR
T1 - Acute respiratory failure survivors' physical, cognitive, and mental health outcomes
T2 - Quantitative measures versus semistructured interviews
AU - Nelliot, Archana
AU - Dinglas, Victor D.
AU - O'Toole, Jacqueline
AU - Patel, Yashika
AU - Mendez-Tellez, Pedro A.
AU - Nabeel, Mohammed
AU - Friedman, Lisa Aronson
AU - Hough, Catherine L.
AU - Hopkins, Ramona O.
AU - Eakin, Michelle N.
AU - Needham, Dale M.
N1 - Funding Information:
Supported by the National Heart, Lung, and Blood Institute (NHLBI) grant R24HL111895. The NHLBI funded the following studies providing data for this research: ALTOS (N01HR56170, R01HL091760, and 3R01HL091760-02S1), ROMA (R01HL096504), and SAILS (contracts HHSN268200536165C to HHSN268200536176C and HHSN268200536179C), along with the Johns Hopkins Institute for Clinical and Translational Research (UL1 TR 000424-06). R.O.H. reports grants from National Institutes of Health NHLBI during the conduct of the study and grants from Intermountain Research and Medical Foundation, outside the submitted work.
Publisher Copyright:
© 2019 by the American Thoracic Society.
PY - 2019
Y1 - 2019
N2 - Rationale: Increasingly, patients are surviving acute respiratory failure (ARF), prompting the need to better understand standardized outcome measures commonly used during ARF follow-up studies. Objectives: Investigate standardized outcome measures (patientreported physical and mental health measures, and cognitive testing) compared with findings from semistructured, qualitative interviews. Methods: As part of two ARF multicenter follow-up studies, standardized outcome measures were obtained, followed by qualitative evaluation via an in-depth, semistructured interview conducted and coded by two independent researchers. Qualitative interviews revealed the following post-ARF survivorship themes: Physical impairment; anxiety, depression, and post-traumatic stress disorder symptoms; and cognitive impairment. Scores from standardized measures related to these themes were compared for ARF survivors reporting versus not reporting these themes in their qualitative interviews. Results: Of 59 invited ARF survivors, 48 (81%) completed both standardized outcome measures and qualitative interviews. Participants' median (interquartile range) age was 53 (43-64) years; 54% were female, and 88% were living independently before hospitalization. The two independent reviewers classifying the presence or absence of themes from the qualitative interviews had excellent agreement (k =0.80).There were significantly worse scores on standardized outcome measures for survivors reporting (vs. not reporting) physical and mental health impairments in their qualitative interviews. However, standardized cognitive test scores did not differ between patients reporting versus not reporting cognitive impairments in their qualitative interviews. Conclusions: These findings support the use of recommended, commonly used standardized outcome measures for physical and mental health impairments in ARF survivorship research. However, caution is needed in interpreting self-reported cognitive function compared with standardized cognitive testing.
AB - Rationale: Increasingly, patients are surviving acute respiratory failure (ARF), prompting the need to better understand standardized outcome measures commonly used during ARF follow-up studies. Objectives: Investigate standardized outcome measures (patientreported physical and mental health measures, and cognitive testing) compared with findings from semistructured, qualitative interviews. Methods: As part of two ARF multicenter follow-up studies, standardized outcome measures were obtained, followed by qualitative evaluation via an in-depth, semistructured interview conducted and coded by two independent researchers. Qualitative interviews revealed the following post-ARF survivorship themes: Physical impairment; anxiety, depression, and post-traumatic stress disorder symptoms; and cognitive impairment. Scores from standardized measures related to these themes were compared for ARF survivors reporting versus not reporting these themes in their qualitative interviews. Results: Of 59 invited ARF survivors, 48 (81%) completed both standardized outcome measures and qualitative interviews. Participants' median (interquartile range) age was 53 (43-64) years; 54% were female, and 88% were living independently before hospitalization. The two independent reviewers classifying the presence or absence of themes from the qualitative interviews had excellent agreement (k =0.80).There were significantly worse scores on standardized outcome measures for survivors reporting (vs. not reporting) physical and mental health impairments in their qualitative interviews. However, standardized cognitive test scores did not differ between patients reporting versus not reporting cognitive impairments in their qualitative interviews. Conclusions: These findings support the use of recommended, commonly used standardized outcome measures for physical and mental health impairments in ARF survivorship research. However, caution is needed in interpreting self-reported cognitive function compared with standardized cognitive testing.
KW - Critical illness
KW - Follow-up studies
KW - Patient outcomes
KW - Qualitative research
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U2 - 10.1513/AnnalsATS.201812-851OC
DO - 10.1513/AnnalsATS.201812-851OC
M3 - Article
C2 - 30844293
AN - SCOPUS:85066762209
SN - 2325-6621
VL - 16
SP - 731
EP - 737
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
IS - 6
ER -