TY - JOUR
T1 - Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes
AU - Fang, Xiaodong
AU - Seim, Inge
AU - Huang, Zhiyong
AU - Gerashchenko, Maxim V.
AU - Xiong, Zhiqiang
AU - Turanov, Anton A.
AU - Zhu, Yabing
AU - Lobanov, Alexei V.
AU - Fan, Dingding
AU - Yim, Sun Hee
AU - Yao, Xiaoming
AU - Ma, Siming
AU - Yang, Lan
AU - Lee, Sang Goo
AU - Kim, Eun Bae
AU - Bronson, Roderick T.
AU - Šumbera, Radim
AU - Buffenstein, Rochelle
AU - Zhou, Xin
AU - Krogh, Anders
AU - Park, Thomas J.
AU - Zhang, Guojie
AU - Wang, Jun
AU - Gladyshev, Vadim N.
N1 - Publisher Copyright:
© 2014 The Authors.
PY - 2014
Y1 - 2014
N2 - Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked molerat (NMR, Heterocephalus glaber). Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression ofoxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.
AB - Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked molerat (NMR, Heterocephalus glaber). Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression ofoxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.
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U2 - 10.1016/j.celrep.2014.07.030
DO - 10.1016/j.celrep.2014.07.030
M3 - Article
C2 - 25176646
AN - SCOPUS:84922541951
SN - 2211-1247
VL - 8
SP - 1354
EP - 1364
JO - Cell Reports
JF - Cell Reports
IS - 5
ER -