Adeno-associated virus finds its disease

David W. Russell; Markus Grompe

doi:10.1038/ng.3407

Adeno-associated virus finds its disease

David W. Russell, Markus Grompe

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.

Original language	English (US)
Pages (from-to)	1104-1105
Number of pages	2
Journal	Nature genetics
Volume	47
Issue number	10
DOIs	https://doi.org/10.1038/ng.3407
State	Published - Sep 29 2015

ASJC Scopus subject areas

Genetics

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title = "Adeno-associated virus finds its disease",

abstract = "Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.",

author = "Russell, {David W.} and Markus Grompe",

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year = "2015",

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AU - Grompe, Markus

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AB - Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.

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Adeno-associated virus finds its disease

Abstract

ASJC Scopus subject areas

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