Adenocarcinoma of the small bowel: Changes in the landscape?

Giovanna Speranza, James H. Doroshow, Shivaani Kummar

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


PURPOSE OF REVIEW: Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advances in characterization, imaging, and treatment of SBA. RECENT FINDINGS: Recent advances in less invasive imaging tools may permit earlier and increased diagnosis of SBA. Surgery remains the mainstay of treatment, and the role of adjuvant chemotherapy is still unclear. However, the use of adjuvant therapy is increasing. Chemotherapy with newer regimens may provide clinical benefit in the metastatic setting. Nearly all results are from retrospective studies. Targeted therapies have not been extensively studied. SUMMARY: The rarity of the disease and difficulty in diagnosis contribute to the lack of prospective trials evaluating therapies for SBA. Retrospective studies suggest a benefit for combination chemotherapy regimens. Prospective evaluation of newer chemotherapeutic agents and targeted therapies is needed to improve outcomes in this disease.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalCurrent Opinion in Oncology
Issue number4
StatePublished - Jul 2010
Externally publishedYes


  • adenocarcinoma
  • chemotherapy
  • small bowel cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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