Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody

Ramon F. Barajas, D. Eric Collins, Soonmee Cha, Michael D. Geschwind

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
Issue number3
StatePublished - Mar 2010
Externally publishedYes


  • Anti-VGKC antibody
  • Encephalopathy
  • Limbic encephalitis
  • Seizure disorder

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody'. Together they form a unique fingerprint.

Cite this