Advanced integrated microelectronic DNA array devices for research, diagnostic and nanofabrication applications

Michael J. Heller

Research output: Contribution to journalConference articlepeer-review


Active microelectronic arrays have been developed for genomic, pharmacogenomic and proteomic research applications and for cancer, genetic and infectious disease diagnostics. These active devices combine the best attributes of both DNA microarray and "lab on a chip" technologies. The electronic microarray devices are able to create re-configurable electric field transport geometries on the array surface, which allows charged reagent and analyte molecules (DNA, RNA, oligonucleotide probes, amplicons antibodies, proteins, enzymes, and cells) to be moved to or from any of the microscopic test sites on the device surface. More recently, CMOS elements have been incorporated into both 400 and 10,000 test site microarray devices providing on-chip current, voltage and addressing control. Considerable efforts have been made to reduce the overall size of the associated instrumentation to produce miniaturized prototype systems for point of care and other biosensor applications. Additionally, these same microelectronic array devices have the potential to be use for nanofabrication applications, including the directed self-assembly of molecular, nanoscale and microscale components into higher order structures. This electric field assisted self-assembly or "Pick and Place Heterogeneous Integration" process may be suitable for fabrication of two and three dimensional devices and structures within defined perimeters of larger silicon or semiconductor structures. This technology has the inherent hierarchical logic of allowing one to control the organization, assembly and communication of structures and components from the molecular scale to the nanoscale to microscale systems.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalDigest of Technical Papers - IEEE International Solid-State Circuits Conference
StatePublished - 2003
Externally publishedYes
EventDigest of Technical Papers - IEEE International Solid-State Circuits Conference: Visuals Supplement - San Francisco, CA., United States
Duration: Feb 15 2003Feb 19 2003

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


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