TY - JOUR
T1 - Advanced magnetic resonance imaging of the physical processes in human Glioblastoma
AU - Kalpathy-Cramer, Jayashree
AU - Gerstner, Elizabeth R.
AU - Emblem, Kyrre E.
AU - Andronesi, Ovidiu C.
AU - Rosen, Bruce
N1 - Publisher Copyright:
© 2014 American Association for Cancer Research.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Themost commonmalignant primary brain tumor, glioblastomamultiforme(GBM) is a devastating disease with a grim prognosis. Patient survival is typically less than two years and fewer than 10% of patients survive more than five years. Magnetic resonance imaging (MRI) can have great utility in the diagnosis, grading, and management of patients withGBMasmany of the physicalmanifestations of the pathologic processes in GBMcan be visualized and quantified using MRI. Newer MRI techniques such as dynamic contrast enhanced and dynamic susceptibility contrastMRI provide functional information about the tumor hemodynamic status. DiffusionMRI can shed light on tumor cellularity and the disruption of white matter tracts in the proximity of tumors.MRspectroscopy can be used to study newtumor tissuemarkers such as IDHmutations.MRI is helping to noninvasively explore the link between the molecular basis of gliomas and the imaging characteristics of their physical processes. We, here, review several approaches toMR-based imaging and discuss the potential for these techniques to quantify the physical processes in glioblastoma, including tumor cellularity and vascularity, metabolite expression, and patterns of tumor growth and recurrence. We conclude with challenges and opportunities for further research in applying physical principles to better understand the biologic process in this deadly disease.
AB - Themost commonmalignant primary brain tumor, glioblastomamultiforme(GBM) is a devastating disease with a grim prognosis. Patient survival is typically less than two years and fewer than 10% of patients survive more than five years. Magnetic resonance imaging (MRI) can have great utility in the diagnosis, grading, and management of patients withGBMasmany of the physicalmanifestations of the pathologic processes in GBMcan be visualized and quantified using MRI. Newer MRI techniques such as dynamic contrast enhanced and dynamic susceptibility contrastMRI provide functional information about the tumor hemodynamic status. DiffusionMRI can shed light on tumor cellularity and the disruption of white matter tracts in the proximity of tumors.MRspectroscopy can be used to study newtumor tissuemarkers such as IDHmutations.MRI is helping to noninvasively explore the link between the molecular basis of gliomas and the imaging characteristics of their physical processes. We, here, review several approaches toMR-based imaging and discuss the potential for these techniques to quantify the physical processes in glioblastoma, including tumor cellularity and vascularity, metabolite expression, and patterns of tumor growth and recurrence. We conclude with challenges and opportunities for further research in applying physical principles to better understand the biologic process in this deadly disease.
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U2 - 10.1158/0008-5472.CAN-14-0383
DO - 10.1158/0008-5472.CAN-14-0383
M3 - Review article
C2 - 25183787
AN - SCOPUS:84907053684
SN - 0008-5472
VL - 74
SP - 4622
EP - 4637
JO - Cancer Research
JF - Cancer Research
IS - 17
ER -