Age-related changes in human and non-human primate white matter: From myelination disturbances to cognitive decline

Steven G. Kohama; Douglas L. Rosene; Larry S. Sherman

doi:10.1007/s11357-011-9357-7

Age-related changes in human and non-human primate white matter: From myelination disturbances to cognitive decline

Steven G. Kohama, Douglas L. Rosene, Larry S. Sherman

Oregon National Primate Research Center

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

Original language	English (US)
Pages (from-to)	1093-1110
Number of pages	18
Journal	Age
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s11357-011-9357-7
State	Published - Oct 2012

Keywords

Aging
Myelination
White matter

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/s11357-011-9357-7

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title = "Age-related changes in human and non-human primate white matter: From myelination disturbances to cognitive decline",

abstract = "The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.",

keywords = "Aging, Myelination, White matter",

author = "Kohama, {Steven G.} and Rosene, {Douglas L.} and Sherman, {Larry S.}",

note = "Funding Information: Acknowledgements This work was supported in part by NIH grants R01 AG031892 (LSS); P51 RR000163 (LSS and SGK; Oregon National Primate Research Center Grant); P01 AG000001 (DLR), R01 AG021133 (DLR), P51 RR000165 (DLR; Yerkes Primate Center Grant).",

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doi = "10.1007/s11357-011-9357-7",

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AU - Rosene, Douglas L.

AU - Sherman, Larry S.

N1 - Funding Information: Acknowledgements This work was supported in part by NIH grants R01 AG031892 (LSS); P51 RR000163 (LSS and SGK; Oregon National Primate Research Center Grant); P01 AG000001 (DLR), R01 AG021133 (DLR), P51 RR000165 (DLR; Yerkes Primate Center Grant).

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N2 - The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

AB - The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

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KW - White matter

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Age-related changes in human and non-human primate white matter: From myelination disturbances to cognitive decline

Abstract

Keywords

ASJC Scopus subject areas

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