Alpha-interferon administration in cytomegalovirus retinitis

S. Chou, J. S. Dylewski, M. W. Gaynon, P. R. Egbert, T. C. Merigan

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number1
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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