Alternative donor hematopoietic stem cell transplantation: A role for umbilical cord blood transplantation for hematologic malignancies

Laura F. Newell; Jonathan A. Gutman; Colleen Delaney

doi:10.1007/978-1-60761-565-1_8

Alternative donor hematopoietic stem cell transplantation: A role for umbilical cord blood transplantation for hematologic malignancies

Laura F. Newell, Jonathan A. Gutman, Colleen Delaney

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hematopoietic stem cell transplantation (HSCT) is a widely accepted therapy with potentially curative benefit for patients with benign and malignant hematologic disorders. There are currently three possible sources of allogeneic hematopoietic stem cells (HSCs) - bone marrow, granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood (PBSC), and umbilical cord blood (CB). Donors can be either related or unrelated and must match recipients at human leukocyte antigens (HLA). Based on the average size of American families, and the 25% probability that a given sibling pair will be HLA-matched, it is estimated that approximately 35% of persons in the United States will have an HLA-matched sibling.

Original language	English (US)
Title of host publication	Leukemia and Related Disorders
Subtitle of host publication	Integrated Treatment Approaches
Publisher	Springer New York
Pages	219-249
Number of pages	31
ISBN (Electronic)	9781607615651
ISBN (Print)	9781607615644
DOIs	https://doi.org/10.1007/978-1-60761-565-1_8
State	Published - Jan 1 2012
Externally published	Yes

Keywords

Alternative donor
Bone marrow
Granulocyte colony-stimulating factor
Hematopoietic stem cell transplantation
Leukemia
Mobilized peripheral blood
Stem cells
Transplantation
Umbilical cord blood

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-60761-565-1_8

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Alternative donor hematopoietic stem cell transplantation: A role for umbilical cord blood transplantation for hematologic malignancies. / Newell, Laura F.; Gutman, Jonathan A.; Delaney, Colleen.
Leukemia and Related Disorders: Integrated Treatment Approaches. Springer New York, 2012. p. 219-249.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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abstract = "Hematopoietic stem cell transplantation (HSCT) is a widely accepted therapy with potentially curative benefit for patients with benign and malignant hematologic disorders. There are currently three possible sources of allogeneic hematopoietic stem cells (HSCs) - bone marrow, granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood (PBSC), and umbilical cord blood (CB). Donors can be either related or unrelated and must match recipients at human leukocyte antigens (HLA). Based on the average size of American families, and the 25% probability that a given sibling pair will be HLA-matched, it is estimated that approximately 35% of persons in the United States will have an HLA-matched sibling.",

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AU - Gutman, Jonathan A.

AU - Delaney, Colleen

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PY - 2012/1/1

Y1 - 2012/1/1

N2 - Hematopoietic stem cell transplantation (HSCT) is a widely accepted therapy with potentially curative benefit for patients with benign and malignant hematologic disorders. There are currently three possible sources of allogeneic hematopoietic stem cells (HSCs) - bone marrow, granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood (PBSC), and umbilical cord blood (CB). Donors can be either related or unrelated and must match recipients at human leukocyte antigens (HLA). Based on the average size of American families, and the 25% probability that a given sibling pair will be HLA-matched, it is estimated that approximately 35% of persons in the United States will have an HLA-matched sibling.

AB - Hematopoietic stem cell transplantation (HSCT) is a widely accepted therapy with potentially curative benefit for patients with benign and malignant hematologic disorders. There are currently three possible sources of allogeneic hematopoietic stem cells (HSCs) - bone marrow, granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood (PBSC), and umbilical cord blood (CB). Donors can be either related or unrelated and must match recipients at human leukocyte antigens (HLA). Based on the average size of American families, and the 25% probability that a given sibling pair will be HLA-matched, it is estimated that approximately 35% of persons in the United States will have an HLA-matched sibling.

KW - Alternative donor

KW - Bone marrow

KW - Granulocyte colony-stimulating factor

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KW - Mobilized peripheral blood

KW - Stem cells

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PB - Springer New York

ER -

Alternative donor hematopoietic stem cell transplantation: A role for umbilical cord blood transplantation for hematologic malignancies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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