Ampa receptors and rapid synaptic transmission

Laurence O. Trussell, Indira M. Raman, Su Zhang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Excitatory synaptic transmission in the vertebrate central nervous system (CNS) is mediated predominantly by glutamate receptors. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate)-sensitive glutamate receptors are endowed with kinetic properties which allow them to transmit fast repetitive signals. At some synapses in the CNS, the rapid onset of desensitization of AMPA receptors limits the duration or amplitude of synaptic events. Combining different AMPA receptor subunits may generate receptors specialized for encoding signals in specific neural pathways. Additionally, synaptic strength may be controlled by protein kinases acting directly on AMPA receptors.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalSeminars in Neuroscience
Issue number2
StatePublished - Apr 1994
Externally publishedYes


  • Glutamate
  • Plasticity
  • Quisqualate

ASJC Scopus subject areas

  • General Neuroscience


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