In previous work we discovered that reductive Pd-mediated aryl-enone cyclization of an advanced intermediate resulted in epimerization of a critical stereocenter. Analysis of conformational and steric effects could rationalize the result. Based on that analysis it was anticipated that a conformational lock could suppress the undesired epimerization. Results reported herein confirm that expectation.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Apr 2 1999|
- Heck Reactions
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry