TY - JOUR
T1 - Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
T2 - Functions and genetic interactions in learning, memory and adult neurogenesis
AU - Weiss, Joseph B.
AU - Xue, Changhui
AU - Benice, Ted
AU - Xue, Liquan
AU - Morris, Stephan W.
AU - Raber, Jacob
N1 - Funding Information:
Supported in part by NCI R01 CA69129 (S.W.M) and by the American Lebanese Syrian Associated Charities (ALSAC) , and St. Jude Children's Research Hospital (L.X., S.W.M.).
PY - 2012/1
Y1 - 2012/1
N2 - Anaplastic Lymphoma Kinase (Alk) is a receptor tyrosine kinase expressed throughout the adult mammalian hippocampus. Recent studies in Drosophila and prior studies in Caenorhabditis elegans have implicated Alk signaling in learning and neurogenesis. We have studied the roles of Alk and the closely related receptor Leukocyte Tyrosine Kinase (Ltk) in learning, behavior and neurogenesis. In the hippocampus, both receptors are expressed throughout the dentate gyrus, CA1 and CA3. To assess the functional roles of Alk and Ltk in the mammalian brain, we analyzed phenotypes in Alk mutant, Ltk mutant and Alk/Ltk double-mutant mice compared to wild-type littermates. Similar to Drosophila, we found enhanced performance in spatial memory in Alk mutant mice. Also similar to Drosophila, we observed reduced neurogenesis associated with loss of Alk function. We also report genetic interactions between Alk and Ltk with respect to neurogenesis and behavioral measures such as activity, anxiety levels, and retention of spatial memory.
AB - Anaplastic Lymphoma Kinase (Alk) is a receptor tyrosine kinase expressed throughout the adult mammalian hippocampus. Recent studies in Drosophila and prior studies in Caenorhabditis elegans have implicated Alk signaling in learning and neurogenesis. We have studied the roles of Alk and the closely related receptor Leukocyte Tyrosine Kinase (Ltk) in learning, behavior and neurogenesis. In the hippocampus, both receptors are expressed throughout the dentate gyrus, CA1 and CA3. To assess the functional roles of Alk and Ltk in the mammalian brain, we analyzed phenotypes in Alk mutant, Ltk mutant and Alk/Ltk double-mutant mice compared to wild-type littermates. Similar to Drosophila, we found enhanced performance in spatial memory in Alk mutant mice. Also similar to Drosophila, we observed reduced neurogenesis associated with loss of Alk function. We also report genetic interactions between Alk and Ltk with respect to neurogenesis and behavioral measures such as activity, anxiety levels, and retention of spatial memory.
KW - Adult neurogenesis
KW - Anaplastic Lymphoma Kinase
KW - Hippocampus
KW - Lymphocyte Tyrosine Kinase
KW - Spatial memory
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U2 - 10.1016/j.pbb.2011.10.024
DO - 10.1016/j.pbb.2011.10.024
M3 - Article
C2 - 22079349
AN - SCOPUS:82655189449
SN - 0091-3057
VL - 100
SP - 566
EP - 574
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 3
ER -