Anatomy and physiology of pain

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Pain is a sensory experience and distinct from nociception, which refers to the neural mechanisms involved in detecting tissue damage. This article reviews nociceptive mechanisms and how these relate to pain sensation. The emphasis is on recent advances in our understanding of nociceptive mechanisms, including transduction at the peripheral nociceptor terminal, ascending pathways, and the cortical role in pain. Plasticity in nociceptive systems and a new role for descending systems in pain facilitation are also discussed.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalSeminars in Neurosurgery
Issue number1
StatePublished - Mar 2004


  • Cortex
  • Modulation
  • Nociceptive mechanisms
  • Plasticity
  • Transduction

ASJC Scopus subject areas

  • Clinical Neurology


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