Anatomy and physiology of pain

Mary M. Heinricher

doi:10.1055/s-2004-830010

Anatomy and physiology of pain

Mary M. Heinricher

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Pain is a sensory experience and distinct from nociception, which refers to the neural mechanisms involved in detecting tissue damage. This article reviews nociceptive mechanisms and how these relate to pain sensation. The emphasis is on recent advances in our understanding of nociceptive mechanisms, including transduction at the peripheral nociceptor terminal, ascending pathways, and the cortical role in pain. Plasticity in nociceptive systems and a new role for descending systems in pain facilitation are also discussed.

Original language	English (US)
Pages (from-to)	5-12
Number of pages	8
Journal	Seminars in Neurosurgery
Volume	15
Issue number	1
DOIs	https://doi.org/10.1055/s-2004-830010
State	Published - Mar 2004

Keywords

Cortex
Modulation
Nociceptive mechanisms
Plasticity
Transduction

ASJC Scopus subject areas

Clinical Neurology

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10.1055/s-2004-830010

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AB - Pain is a sensory experience and distinct from nociception, which refers to the neural mechanisms involved in detecting tissue damage. This article reviews nociceptive mechanisms and how these relate to pain sensation. The emphasis is on recent advances in our understanding of nociceptive mechanisms, including transduction at the peripheral nociceptor terminal, ascending pathways, and the cortical role in pain. Plasticity in nociceptive systems and a new role for descending systems in pain facilitation are also discussed.

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KW - Plasticity

KW - Transduction

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Anatomy and physiology of pain

Abstract

Keywords

ASJC Scopus subject areas

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